Gosnell B A, Levine A S, Morley J E
Life Sci. 1986 Mar 24;38(12):1081-8. doi: 10.1016/0024-3205(86)90243-2.
It is known that under some conditions the administration of opioid agonists will stimulate food intake. However, the lack of receptor selectivity of some of the agonists which produce this effect leaves open the question of which receptor types are actually involved. In the experiments presented here, rats were given intracerebroventricular injections of Dynorphin 1-17 (DYN), [D-ala2MePhe4,-Gly-ol5]enkephalin (DAGO), and [D-ser2, leu5]enkephalin-thr6 (DSLET); these peptides are thought to be selective agonists at kappa, mu and delta opioid receptors, respectively. All three peptides stimulated food intake in non-deprived rats at doses in the 3-10 nmol range; water intake was also increased in some cases. Generally, DYN stimulated feeding at a lower dose than DAGO or DSLET and the magnitude of the effect tended to be greater. On the other hand, DAGO more consistently increased water intake. In some cases, DYN also caused episodes of "barrel-rolling" and postural abnormalities, whereas DAGO had sedative and/or cataleptic effects. These results are interpreted as an involvement of more than one opioid receptor types in the regulation of appetite, possibly with separate opioid systems contributing to food and water intake.
已知在某些情况下，给予阿片类激动剂会刺激食物摄入。然而，一些产生这种效应的激动剂缺乏受体选择性，这使得究竟哪些受体类型实际参与其中的问题悬而未决。在本文所呈现的实验中，给大鼠脑室内注射强啡肽1 - 17（DYN）、[D - 丙氨酸² - 甲硫氨酸⁴ - 甘氨酸 - 醇⁵]脑啡肽（DAGO）和[D - 丝氨酸²，亮氨酸⁵]脑啡肽 - 苏氨酸⁶（DSLET）；这些肽分别被认为是κ、μ和δ阿片受体的选择性激动剂。所有这三种肽在3 - 10纳摩尔范围内的剂量下均刺激未禁食大鼠的食物摄入；在某些情况下水摄入量也增加。一般来说，DYN以比DAGO或DSLET更低的剂量刺激进食，且效应程度往往更大。另一方面，DAGO更持续地增加水摄入量。在某些情况下，DYN还会引起“翻滚”发作和姿势异常，而DAGO具有镇静和/或僵住效应。这些结果被解释为不止一种阿片受体类型参与食欲调节，可能不同的阿片系统分别影响食物和水的摄入。
