Barone Gibbs Bethany, Kowalsky Robert J, Perdomo Sophy J, Taormina John M, Balzer Jeffrey R, Jakicic John M
aDepartment of Health and Physical Activity bDepartment of Neurological Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
J Hypertens. 2017 Dec;35(12):2411-2418. doi: 10.1097/HJH.0000000000001463.
Reducing prolonged sitting at work has been recommended by an expert panel, but whether intermittent standing improves vascular health is unclear. We aimed to test whether using a sit-stand desk could reduce blood pressure (BP) and pulse wave velocity (PWV) during a simulated workday.
Overweight/obese adults with pre-to-Stage 1 hypertension completed a randomized crossover study with two simulated workday conditions: STAND-SIT (alternating standing and sitting condition every 30 min) and SIT (continuous sitting condition). Oscillometric BP was measured hourly. Carotid-femoral, carotid-radial, and carotid-ankle PWV were measured in the morning, mid-day, and late afternoon using tonometry.
Participants [n = 25, 64% male, 84% white, mean (SD) age: 42 (12) years] had average resting SBP of 132 (9) mmHg and DBP of 83 (8) mmHg. In linear mixed models, STAND-SIT resulted in a significantly lower DBP (mean ± SE: -1.0 ± 0.4 mmHg, P = 0.020) and mean arterial pressure (MAP) (-1.0 ± 0.4 mmHg, P = 0.029) compared with SIT. SBP (-0.9 ± 0.7 mmHg, P = 0.176) was not different across conditions. Carotid-ankle PWV was significantly lower during the STAND-SIT vs. SIT condition (-0.27 ± 0.13 m/s, P = 0.047), whereas carotid-femoral PWV (-0.03 ± 0.13 m/s, P = 0.831) and carotid-radial PWV (-0.30 ± 0.18 m/s, P = 0.098) were not. Changes in MAP partially explained changes in PWV.
Interrupting prolonged sitting during deskwork with intermittent standing was a sufficient stimulus to slightly, but statistically significantly, decrease DBP, MAP, and carotid-ankle PWV. Though the clinical significance of the observed effects is modest, regular use of a sit-stand desk may be a practical way to lower BP and PWV while performing deskwork.
一个专家小组建议减少工作中的久坐时间，但间歇性站立是否能改善血管健康尚不清楚。我们旨在测试使用升降桌是否能在模拟工作日期间降低血压（BP）和脉搏波速度（PWV）。
超重/肥胖的1期高血压前期成年人完成了一项随机交叉研究，该研究有两种模拟工作日条件：站立-坐下（每30分钟交替站立和坐下）和持续坐着。每小时测量一次示波血压。使用眼压测量法在上午、中午和下午晚些时候测量颈股、颈桡和颈踝PWV。
参与者[n = 25，64%为男性，84%为白人，平均（标准差）年龄：42（12）岁]的静息收缩压平均为132（9）mmHg，舒张压为83（8）mmHg。在线性混合模型中，与持续坐着相比，站立-坐下导致舒张压显著降低（均值±标准误：-1.0±0.4mmHg，P = 0.020）和平均动脉压（MAP）降低（-1.0±0.4mmHg，P = 0.029）。收缩压在不同条件下无差异（-0.9±0.7mmHg，P = 0.176）。与持续坐着相比，站立-坐下条件下颈踝PWV显著降低（-0.27±0.13m/s，P = 0.047），而颈股PWV（-0.03±0.13m/s，P = 0.831）和颈桡PWV（-0.30±0.18m/s，P = 0.098）无差异。MAP的变化部分解释了PWV的变化。
在伏案工作期间通过间歇性站立打断长时间坐着是一种足够的刺激，可轻微但在统计学上显著降低舒张压、MAP和颈踝PWV。尽管观察到的效果的临床意义不大，但经常使用升降桌可能是在进行伏案工作时降低血压和PWV的一种实用方法。
