Legge M, Potter H C
N Z Med J. 1986 Mar 12;99(797):159-62.
Gamma glutamyl transpeptidase (GGTP) activity was determined in second trimester amniotic fluid taken from normal fetuses and those with fetal abnormalities. GGTP activity decreased with advancing gestation. Increasing meconium contamination correlated with an increase in GGTP activity as did increasing fetal blood contamination. Maternal blood did not affect GGTP activity. Anencephaly did not significantly alter the GGTP activity, however, fetuses with spina bifida had significantly lower activity. Klinefelters and Turners syndromes both had GGTP activity close to the 50th percentile, and two trisomy 21 fetuses had GGTP activity below the 40th percentile. Two trisomy 18 fetuses and two translocation Downs syndromes (46 XY, t (14;21) had GGTP activities considerably lower than the 20th percentile as did a fetus with gastroschisis. Second trimester amniotic fluid GGTP activity may provide an easy preliminary test to screen amniotic fluids for the possibility of certain fetal chromosome abnormalities.
测定了取自正常胎儿和有胎儿异常的胎儿的孕中期羊水γ-谷氨酰转肽酶（GGTP）活性。GGTP活性随孕周增加而降低。胎粪污染增加与GGTP活性增加相关，胎儿血液污染增加时情况亦如此。母体血液不影响GGTP活性。无脑儿并未显著改变GGTP活性，然而，脊柱裂胎儿的GGTP活性显著较低。克兰费尔特综合征和特纳综合征的GGTP活性均接近第50百分位数，两名21三体胎儿的GGTP活性低于第40百分位数。两名18三体胎儿和两名易位型唐氏综合征（46 XY，t（14；21））的GGTP活性远低于第20百分位数，腹裂胎儿的情况也是如此。孕中期羊水GGTP活性可能为筛查羊水是否存在某些胎儿染色体异常提供一种简便的初步检测方法。
