Shi Yuanyuan, Li Yuqian, Wang Jinjin, Wang Chongjian, Fan Jingjing, Zhao Jingzhi, Yin Lei, Liu Xuejiao, Zhang Dongdong, Li Linlin
Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China.
Department of Clinical Pharmacology, School of Pharmaceutical Science, Zhengzhou University, Zhengzhou, Henan, PR China.
PLoS One. 2017 Jul 13;12(7):e0181232. doi: 10.1371/journal.pone.0181232. eCollection 2017.
To collectively evaluate the association of glucose-6-phosphatase catalytic unit 2 (G6PC2) allele variants with elevated fasting glucose (FG) and type 2 diabetes (T2D).
Meta-analysis.
PubMed, Web of Knowledge and Embase databases.
Full text articles of studies that identified an association of G6PC2 with T2D and elevated FG.
There was no T2D patient involvement in the analyses on the association of FG with G6PC2, there were T2D patients and non-diabetes patient involvement in the analyses on the association of T2D with G6PC2.
Random-effects meta-analyses were used to calculate the pool effect sizes. I2 metric and H2 tests were used to calculate the heterogeneity. Begg's funnel plot and Egger's linear regression test were done to assess publication bias.
Of the 423 studies identified, 21 were eligible and included. Data on three loci (rs560887, rs16856187 and rs573225) were available. The G allele at rs560887 in three ethnicities, the C allele at rs16856187 and the A allele at rs573225 all had a positive association with elevated FG. Per increment of G allele at rs560887 and A allele at rs573225 resulted in a FG 0.070 mmol/l and 0.075 mmol/l higher (ß (95% CI) = 0.070 (0.060, 0.079), p = 4.635e-50 and 0.075 (0.065, 0.085), p = 5.856e-48, respectively). With regard to the relationship of rs16856187 and FG, an increase of 0.152 (95% CI: 0.034-0.270; p = 0.011) and 0.317 (95% CI: 0.193-0.442, p = 6.046e-07) was found in the standardized mean difference (SMD) of FG for the AC and CC genotypes, respectively, when compared with the AA reference genotype. However, the G-allele of rs560887 in Caucasians under the additive model and the C-allele of rs16856187 under the allele and dominant models were associated with a decreased risk of T2D (OR (95% CI) = 0.964 (0.947, 0.981), p = 0.570e-4; OR (95% CI) = 0.892 (0.832, 0.956), p = 0.001; and OR (95% CI) = 0.923(0.892, 0.955), p = 5.301e-6, respectively).
Our meta-analyses demonstrate that all three allele variants of G6PC2 (rs560887, rs16856187 and rs573225) are associated with elevated FG, with two variants (rs560887 in the Caucasians subgroup and rs16856187 under the allele and dominant model) being associated with T2D as well. Further studies utilizing larger sample sizes and different ethnic populations are needed to extend and confirm these findings.
综合评估葡萄糖-6-磷酸酶催化亚基2（G6PC2）等位基因变异与空腹血糖升高（FG）及2型糖尿病（T2D）之间的关联。
荟萃分析。
PubMed、Web of Knowledge和Embase数据库。
确定G6PC2与T2D及FG升高存在关联的研究的全文文章。
在FG与G6PC2关联分析中未纳入T2D患者，在T2D与G6PC2关联分析中纳入了T2D患者和非糖尿病患者。
采用随机效应荟萃分析计算合并效应量。使用I²指标和H²检验计算异质性。采用Begg漏斗图和Egger线性回归检验评估发表偏倚。
在检索到的423项研究中，21项符合纳入标准并被纳入。有三个位点（rs560887、rs16856187和rs573225）的数据可用。rs560887位点的G等位基因在三个种族中、rs16856187位点的C等位基因以及rs573225位点的A等位基因均与FG升高呈正相关。rs560887位点的G等位基因和rs573225位点的A等位基因每增加一个，FG分别升高0.070 mmol/L和0.075 mmol/L（β(95%CI)=0.070(0.060,0.079)，p = 4.635e-50；0.075(0.065,0.085)，p = 5.856e-48）。关于rs1685618
