病毒之战：LC3 招募 GTPases。
War on Viruses: LC3 Recruits GTPases.
机构信息
Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
出版信息
Cell Host Microbe. 2017 Jul 12;22(1):7-9. doi: 10.1016/j.chom.2017.06.019.
PMID:28704655
Abstract
Interferon effector functions and autophagy are evolutionarily conserved arms of cell-autonomous immunity that restrict replication of intracellular pathogens. In this issue of Cell Host and Microbe, Biering et al., (2017) demonstrate how host cells co-opt sequential action of autophagy proteins and IFN-inducible GTPases to inhibit replication of positive-sense RNA viruses.
摘要
干扰素效应功能和自噬是细胞自主免疫中进化保守的分支，可限制细胞内病原体的复制。在本期《细胞宿主与微生物》中，Biering 等人（2017 年）展示了宿主细胞如何共同利用自噬蛋白和 IFN 诱导的 GTPases 的连续作用来抑制正链 RNA 病毒的复制。
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