Committee on Microbiology, The University of Chicago, Chicago, IL 60637, USA.
Committee on Immunology, The University of Chicago, Chicago, IL 60637, USA.
Viruses. 2019 Mar 12;11(3):244. doi: 10.3390/v11030244.
Autophagy is an essential cellular process by which a cell degrades materials within its cytoplasm. Intracellular pathogens like viruses must deal with autophagy, either positively or negatively, for their own survival and replication. For some viruses, autophagy can even play proviral roles, helping their replication or dissemination. For other viruses, including noroviruses, the exact role of autophagy is more complex. This short review seeks to summarize the known interactions between autophagy, autophagy proteins and norovirus, and to address remaining questions relevant to these interactions.
自噬是一种细胞内的基本降解过程，通过该过程，细胞降解细胞质内的物质。病毒等细胞内病原体必须应对自噬，无论是积极的还是消极的，以维持其自身的生存和复制。对于某些病毒来说，自噬甚至可以起到辅助病毒复制或传播的作用。而对于其他病毒，包括诺如病毒，自噬的具体作用则更加复杂。本文旨在概述自噬、自噬蛋白与诺如病毒之间的已知相互作用，并探讨与这些相互作用相关的一些悬而未决的问题。
