Klein Robyn S
Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA; Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA; Department of Neuroscience, Washington University School of Medicine, St Louis, MO 63110, USA.
Cell Host Microbe. 2017 Jul 12;22(1):9-11. doi: 10.1016/j.chom.2017.06.015.
Infection with Zika virus (ZIKV) during pregnancy may cause severe developmental defects in the human brain via unknown mechanisms. In a recent issue of Science, Chavali et al. (2017) identified a neural progenitor cell (NPC)-specific RNA binding protein that may underlie the high levels of ZIKV replication and apoptosis observed in these cells during congenital infections.
孕期感染寨卡病毒(ZIKV)可能通过未知机制导致人类大脑出现严重发育缺陷。在最近一期的《科学》杂志上,查瓦利等人(2017年)鉴定出一种神经祖细胞(NPC)特异性RNA结合蛋白,该蛋白可能是先天性感染期间在这些细胞中观察到的高水平寨卡病毒复制和凋亡的基础。