State Key Laboratory of Environmental Aquatic Chemistry, Research Centre for Eco-Environmental Science, Chinese Academy of Sciences, Beijing 100085, China; University of Chinese Academy of Sciences, Beijing 100085, China.
State Key Laboratory of Environmental Aquatic Chemistry, Research Centre for Eco-Environmental Science, Chinese Academy of Sciences, Beijing 100085, China.
Sci Total Environ. 2017 Dec 31;607-608:509-518. doi: 10.1016/j.scitotenv.2017.06.140. Epub 2017 Jul 27.
The wide application of nanoparticles will lead its release into the aquatic environment, which may alter the bioavailability and toxicity of other contaminants to aquatic organisms. This work aimed to study the effects of perfluorooctane sulfonate (PFOS), single-wall carbon nanotubes (SWCNT), and their mixture on PFOS accumulation, antioxidant defenses and acetylcholinesterase (AChE) activity in zebrafish. The fish was dissected after being exposed (24, 48, 72 and 96h) separately to PFOS, SWCNT and PFOS+SWCNT co-exposure. The bioaccumulation of PFOS in fish tissues (liver, intestines, gills and brain) decreased with increasing dosage of SWCNT, however, the opposite trend was observed in fish skin, which indicated that the bioavailability of PFOS changed by adsorption on SWCNT. Meanwhile, co-exposure induced more reactive oxygen species (ROS) than PFOS alone and enhanced the effect of PFOS on the superoxide dismutase (SOD), and catalase (CAT) and AChE activities. Furthermore, the integrated biomarker response (IBR) showed that co-exposure was the most stressful circumstance.
纳米粒子的广泛应用将导致其释放到水生环境中，这可能会改变其他污染物对水生生物的生物利用度和毒性。本工作旨在研究全氟辛烷磺酸（PFOS）、单壁碳纳米管（SWCNT）及其混合物对斑马鱼中 PFOS 积累、抗氧化防御和乙酰胆碱酯酶（AChE）活性的影响。在分别暴露于 PFOS、SWCNT 和 PFOS+SWCNT 共暴露 24、48、72 和 96 小时后，对鱼进行解剖。PFOS 在鱼组织（肝脏、肠道、鳃和大脑）中的生物累积随 SWCNT 剂量的增加而减少，但在鱼皮中观察到相反的趋势，这表明 PFOS 的生物利用度因吸附在 SWCNT 上而发生了变化。同时，共暴露比单独 PFOS 产生更多的活性氧（ROS），并增强了 PFOS 对超氧化物歧化酶（SOD）、过氧化氢酶（CAT）和 AChE 活性的影响。此外，综合生物标志物响应（IBR）表明共暴露是最具压力的情况。
