Descloux Emilienne, Augsburger Marc, Teresiński Grzegorz, Hejna Petr, Grouzmann Eric, Scarpelli Maria Pia, Hervet Tania, Palmiere Cristian
University Centre of Legal Medicine, Lausanne University Hospital (CHUV), Lausanne, Switzerland.
Chair and Department of Forensic Medicine, Medical University of Lublin, Lublin, Poland.
J Forensic Leg Med. 2017 Aug;50:39-43. doi: 10.1016/j.jflm.2017.07.002. Epub 2017 Jul 4.
Endocan is a soluble molecule secreted from vascular endothelial cells of various organs. Its exact function in humans remains to be elucidated, though it has been postulated that increased tissue expression or serum levels of this molecule may be an indicator of endothelial activation and neovascularization. In the realm of forensic pathology, studies pertaining to endothelial activation following exposure to cold exclusively focused on thrombomodulin, a transmembrane protein specific to endothelial cells. In the study herein described, endocan concentrations were determined in postmortem serum, urine and vitreous humor samples collected during autopsy in a series of cases that underwent medicolegal investigations. A total of 76 autopsy cases were selected and three study groups (hypothermia group, sepsis group and non-hypothermia/non-sepsis group) prospectively formed during the study period. The obtained results seem to indicate that exposure to cold and subsequent death is not distinguished by significant endothelial dysfunction causing enhanced endocan secretion.
内脂素是一种由各种器官的血管内皮细胞分泌的可溶性分子。尽管有人推测该分子的组织表达增加或血清水平升高可能是内皮激活和新血管形成的指标，但其在人类中的确切功能仍有待阐明。在法医病理学领域，关于暴露于寒冷后内皮激活的研究仅聚焦于血栓调节蛋白，这是一种内皮细胞特有的跨膜蛋白。在本文所述的研究中，在一系列接受法医学调查的病例尸检期间收集的死后血清、尿液和玻璃体液样本中测定了内脂素浓度。总共选择了76例尸检病例，并在研究期间前瞻性地形成了三个研究组（体温过低组、败血症组和非体温过低/非败血症组）。获得的结果似乎表明，暴露于寒冷及随后的死亡并非以导致内脂素分泌增加的显著内皮功能障碍为特征。
