Fouda Mona A, Turkestani Iqbal Z, Almusharraf Sara, Al-Ajlan Abdulrahman, Angkaya-Bagayawa Fatima F, Sabico Shaun, Mohammed Ashry Gad, Hassanato Rana, Al-Serehi Amal, Alshingetti Naemah M, Al-Daghri Nasser M
Endocrinology Division, Department of Medicine, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Neonatology. 2017;112(3):225-230. doi: 10.1159/000475704. Epub 2017 Jul 14.
Vitamin D deficiency is a global public health problem. The published literature on vitamin D deficiency is limited among Arab pregnant women and its association with different metabolic markers.
To determine the prevalence of vitamin D deficiency in Arab pregnant women and neonates and its association with various biomarker profiles.
This is a multicenter study taken from a large prospective project in Riyadh, the capital city of Saudi Arabia. Maternal biochemical levels were measured routinely. Maternal and neonatal 25(OH)D levels were assessed using a chemiluminescence immunoassay. A total of 1,097 pregnant women >16 years old with gestational ages <24 weeks were recruited from different tertiary hospitals in Riyadh between February 2011 and June 2012.
Almost 85% of pregnant subjects had 25(OH)D level <50 nmol/L. Vitamin D deficiency among neonates was 88%. Maternal 25(OH)D was significantly associated with neonatal 25(OH)D (r = 0.54, p < 0.01), as well as serum calcium (r = 0.16, p = 0.02) and phosphate levels (r = 0.17, p = 0.02), and had an inverse correlation with parathyroid hormone (r = -0.22, p = 0.001).
Maternal and neonatal vitamin D deficiency is alarmingly high in Arabs and significantly associated with each another. Universal screening for serum 25(OH)D may be appropriate for Arab mothers and vitamin D supplementation mandatory until term. The study puts a spotlight on vitamin D deficiency with the hope that health professionals will address it adequately to prevent the known long-term consequences for metabolism and bone health of both mothers and their children.
维生素D缺乏是一个全球性的公共卫生问题。关于阿拉伯孕妇维生素D缺乏及其与不同代谢标志物关联的已发表文献有限。
确定阿拉伯孕妇和新生儿维生素D缺乏的患病率及其与各种生物标志物谱的关联。
这是一项多中心研究，取自沙特阿拉伯首都利雅得的一个大型前瞻性项目。常规测量孕妇的生化指标。采用化学发光免疫分析法评估孕妇和新生儿的25(OH)D水平。2011年2月至2012年6月期间，从利雅得不同的三级医院招募了1097名年龄大于16岁、孕周小于24周的孕妇。
近85%的孕妇25(OH)D水平<50 nmol/L。新生儿维生素D缺乏率为88%。孕妇的25(OH)D与新生儿的25(OH)D显著相关（r = 0.54，p < 0.01），与血清钙（r = 0.16，p = 0.02）和磷酸盐水平（r = 0.17，p = 0.02）也显著相关，与甲状旁腺激素呈负相关（r = -0.22，p = 0.001）。
阿拉伯人孕妇和新生儿维生素D缺乏情况惊人地高，且两者之间显著相关。对阿拉伯母亲进行血清25(OH)D的普遍筛查可能是合适的，并且在足月前必须补充维生素D。该研究突出了维生素D缺乏问题，希望健康专业人员能充分应对，以预防已知的母亲及其子女代谢和骨骼健康方面的长期后果。
