Cesar L, Gonzalez C, Calia F M
Arch Intern Med. 1975 May;135(5):711-4. doi: 10.1001/archinte.135.5.711.
The role of anaerobic and aerobic microorganisms in the genesis of pneumonia or lung abscess in patients with historical, clinical, and radiologic findings suggestive of aspiration was compared to their role in similar patients without these findings. Bacterial specimens were obtained by transtracheal aspiration or thoracentesis. Anaerobes were isolated in 100% of the patients who were aspiration-prone as contrasted with only 20% of those who were not. Isolation of a single species or no growth was more common in the nonaspiration group, whereas multiple isolates were more common in the aspiration group. Patients with lung abscesses were treated with penicillin and all of them responded clinically, despite occasional recovery from the culture specimen of penicillin-resistant organisms. This suggests that lung abscess may be the result of a synergistic bacterial infection.
将有病史、临床及影像学表现提示有误吸的患者发生肺炎或肺脓肿时厌氧和需氧微生物的作用，与无这些表现的类似患者中这些微生物的作用进行了比较。通过经气管抽吸或胸腔穿刺获取细菌标本。在易发生误吸的患者中，100%分离出厌氧菌，而在不易发生误吸的患者中仅20%分离出厌氧菌。在非误吸组中，分离出单一菌种或无生长更为常见，而在误吸组中多个分离株更为常见。肺脓肿患者接受青霉素治疗，尽管偶尔从耐青霉素菌的培养标本中恢复，但所有患者临床症状均有改善。这表明肺脓肿可能是一种协同细菌感染的结果。
