Adegbola R A, Falade A G, Sam B E, Aidoo M, Baldeh I, Hazlett D, Whittle H, Greenwood B M, Mulholland E K
Medical Research Council Laboratories, Banjul, Gambia.
Pediatr Infect Dis J. 1994 Nov;13(11):975-82. doi: 10.1097/00006454-199411000-00008.
During a 2-year period 159 malnourished children ages 3 months to 5 years with radiologic evidence of pneumonia were investigated to determine the cause of their pneumonia. In addition 119 malnourished children without pneumonia, 119 well-nourished children with pneumonia and 52 well-nourished children without pneumonia were studied as controls. Percutaneous lung aspiration was performed on 35 malnourished and 59 well-nourished children with pneumonia. Bacteria were isolated from the blood, lung or pleural fluid of 28 (18%) malnourished children with pneumonia, 42 (35%) well-nourished children with pneumonia and from the blood of 5 (4%) malnourished children without pneumonia. Streptococcus pneumoniae and Haemophilus influenzae, which were the two organisms isolated most frequently in both groups of children with pneumonia, were found in 17 (11%) malnourished and 39 (33%) well-nourished children with pneumonia. Mycobacterium tuberculosis was detected in 5 malnourished children with pneumonia. A potentially pathogenic virus was identified in 35% of malnourished children with pneumonia and 40% of well-nourished children with pneumonia, and from 25% of children without pneumonia. The viruses identified most frequently were adenovirus and respiratory syncytial virus.(ABSTRACT TRUNCATED AT 250 WORDS)
在两年期间，对159名年龄在3个月至5岁、有肺炎放射学证据的营养不良儿童进行了调查，以确定其肺炎病因。此外，还对119名无肺炎的营养不良儿童、119名有肺炎的营养良好儿童和52名无肺炎的营养良好儿童作为对照进行了研究。对35名营养不良和59名营养良好的肺炎儿童进行了经皮肺穿刺抽吸。从28名（18%）患有肺炎的营养不良儿童、42名（35%）患有肺炎的营养良好儿童的血液、肺或胸腔积液中分离出细菌，以及从5名（4%）无肺炎的营养不良儿童的血液中分离出细菌。肺炎链球菌和流感嗜血杆菌是两组肺炎儿童中最常分离出的两种病原体，在17名（11%）患有肺炎的营养不良儿童和39名（33%）患有肺炎的营养良好儿童中被发现。在5名患有肺炎的营养不良儿童中检测到结核分枝杆菌。在35%的患有肺炎的营养不良儿童、40%的患有肺炎的营养良好儿童以及25%的无肺炎儿童中鉴定出一种潜在致病性病毒。最常鉴定出的病毒是腺病毒和呼吸道合胞病毒。（摘要截短至250字）
