Gram L F, Christensen P
Pharmacopsychiatry. 1986 Jan;19(1):19-22. doi: 10.1055/s-2007-1017143.
Clinical studies on spontaneous afternoon cortisol levels in depressed patients revealed that oxazepam given a few hours before blood sampling, may suppress the cortisol levels. This was confirmed in a volunteer study, where oxazepam 30 and 60 mg caused a dose-dependent suppression of the cortisol level only lasting 2 or 3 hours in spite of persisting high oxazepam levels in plasma. Subsequently, a study in 28 depressed patients showed a substantial suppression of afternoon cortisol after oxazepam 45 mg given 2 hrs prior to sampling. It may be postulated that this effect is mediated through GABA-ergic receptors inhibiting the hypothalamic release of corticotropin releasing factor (CRF). This is interesting since CRF may have neurotropic effects related to the behavioral responses to stress, and the inhibitory effect thus may represent a mechanism of action for the anxiolytic effect of benzodiazepines.
对抑郁症患者自发性下午皮质醇水平的临床研究表明，在采血前数小时给予奥沙西泮可能会抑制皮质醇水平。这在一项志愿者研究中得到了证实，在该研究中，30毫克和60毫克的奥沙西泮导致皮质醇水平呈剂量依赖性抑制，尽管血浆中奥沙西泮水平持续较高，但这种抑制仅持续2或3小时。随后，一项对28名抑郁症患者的研究表明，在采样前2小时给予45毫克奥沙西泮后，下午皮质醇受到显著抑制。可以推测，这种作用是通过γ-氨基丁酸能受体介导的，该受体抑制促肾上腺皮质激素释放因子（CRF）从下丘脑的释放。这很有趣，因为CRF可能具有与对应激的行为反应相关的神经营养作用，因此这种抑制作用可能代表了苯二氮䓬类药物抗焦虑作用的一种作用机制。
