Luyk N H, Boyle M A, Ward-Booth R P
Anesth Prog. 1987 Mar-Apr;34(2):37-42.
Thirty three healthy patients (ASA 1) who required the removal of impacted third molars were included in a double-blind cross-over trial to compare the amnestic and anxiolytic efficacy of diazepam and midazolam. The anxiolytic properties of the two drugs were assessed objectively by the measurement of changes in blood pressure, pulse rate, plasma cortisol levels, and subjectively by a patient assessment using a visual analogue scale for anxiety. The amnestic properties were evaluated by patient's ability to recall two visual stimuli they were shown. The first drug given was titrated to clinical sedation and the second drug was given in an "equipotent" ratio of 1.0 midazolam to 2.86 diazepam. There was a statistically significant fall in anxiety and good levels of amnesia achieved using both drugs. No statistical differences were detected between the two drugs.
33名需要拔除阻生第三磨牙的健康患者（ASA 1级）被纳入一项双盲交叉试验，以比较地西泮和咪达唑仑的遗忘和抗焦虑疗效。通过测量血压、脉搏率、血浆皮质醇水平客观评估两种药物的抗焦虑特性，并通过患者使用视觉模拟焦虑量表进行主观评估。通过患者回忆所展示的两个视觉刺激的能力来评估遗忘特性。给予的第一种药物滴定至临床镇静水平，第二种药物以1.0咪达唑仑比2.86地西泮的“等效”比例给予。两种药物使用后焦虑均有统计学显著下降且达到了良好的遗忘水平。两种药物之间未检测到统计学差异。
