Christensen P, Gram L F, Lolk A, Kragh-Sørensen P
Department of Clinical Pharmacology, Odense University, Denmark.
J Affect Disord. 1987 Nov-Dec;13(3):273-8. doi: 10.1016/0165-0327(87)90047-4.
In 72 hospitalized depressed patients afternoon plasma cortisol (15.00-15.20) was measured in three ways: spontaneous (n = 72), 16 h after administration of 2 mg dexamethasone (n = 71) and 2 h after administration of 45 mg oxazepam (n = 28) or 60 mg oxazepam (n = 37). When cortisol values were log-transformed the histograms and probit functions of spontaneous cortisol levels and cortisol levels after oxazepam suppression suggested log-normal distributions. However, for cortisol levels after suppression with dexamethasone the probit function was sigmoidal, suggesting non-normality. In addition the histogram for this parameter had two peaks. The most pronounced suppression with dexamethasone was obtained in patients with low spontaneous cortisol levels. In contrast the somewhat weaker cortisol suppressing effect of 45 or 60 mg oxazepam appeared not to be influenced by the spontaneous cortisol level.
对72例住院抑郁症患者采用三种方法测量下午血浆皮质醇（时间为15:00 - 15:20）：自然状态下测量（n = 72）；给予2毫克地塞米松16小时后测量（n = 71）；给予45毫克奥沙西泮2小时后测量（n = 28）或给予60毫克奥沙西泮2小时后测量（n = 37）。当对皮质醇值进行对数转换后，自然状态下皮质醇水平以及奥沙西泮抑制后皮质醇水平的直方图和概率单位函数显示呈对数正态分布。然而，地塞米松抑制后皮质醇水平的概率单位函数呈S形，表明其不呈正态分布。此外，该参数的直方图有两个峰值。地塞米松对自然皮质醇水平低的患者抑制作用最为明显。相比之下，45毫克或60毫克奥沙西泮对皮质醇的抑制作用稍弱，且似乎不受自然皮质醇水平的影响。
