Ghiasi Maryam, Daneshpazhooh Maryam, Ismonov Muhammadkhuja, Chams-Davatchi Cheyda
Department of Dermatology, Autoimmune Bullous Diseases Research Center, Tehran University of Medical Sciences, Tehran, Iran;
Department of Dermatology, Autoimmune Bullous Diseases Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Skinmed. 2017 Jun 1;15(3):175-180. eCollection 2017.
Autoimmune bullous diseases (ABDs) are uncommon but significant skin disorders with relatively high morbidity and mortality. Some surveys have been carried out to describe the spectrum of ABDs in a region, but this is the first that has focused on ABDs in elderly patients. This study was conducted to determine the clinicoepidemiologic features of ABDs in elderly patients. Medical records of all ABD patients with disease onset after the age of 60 years who presented to the Autoimmune Bullous Diseases Research Center, Tehran, Iran between April 2003 and March 2013 were reviewed. Patients with dermatitis herpetiformis were not included. During the 10-year period studied, 296 patients with ABD and disease onset after 60 years of age were diagnosed. Bullous pemphigoid (BP) was observed to be the most common ABD (48.3%), followed by pemphigus vulgaris (45.3%), pemphigus foliaceus (3.7%), mucous membrane pemphigoid (1.4%), paraneoplastic pemphigus (0.7%), epidermolysis bullosa acquisita (0.3%), and linear IgA bullous disease (0.3%). A predominance in women was observed for total ABDs, BP, and pemphigus vulgaris. Although Iran is known to have a high prevalence of pemphigus, BP is the most frequent ABD among elderly patients in Iran, highlighting the importance of the clinical diagnosis of BP in elderly patients.
自身免疫性大疱性疾病（ABDs）虽不常见，但却是严重的皮肤疾病，发病率和死亡率相对较高。已有一些调查描述了某一地区ABDs的疾病谱，但这是首次聚焦于老年患者的ABDs研究。本研究旨在确定老年患者ABDs的临床流行病学特征。回顾了2003年4月至2013年3月期间就诊于伊朗德黑兰自身免疫性大疱性疾病研究中心、60岁后发病的所有ABDs患者的病历。疱疹样皮炎患者未纳入研究。在研究的10年期间，共诊断出296例60岁后发病的ABDs患者。观察发现，大疱性类天疱疮（BP）是最常见的ABDs（48.3%），其次是寻常型天疱疮（45.3%）、落叶型天疱疮（3.7%）、黏膜类天疱疮（1.4%）、副肿瘤性天疱疮（0.7%）、获得性大疱性表皮松解症（0.3%）和线状IgA大疱性疾病（0.3%）。在所有ABDs、BP和寻常型天疱疮中，女性占主导。尽管伊朗已知天疱疮患病率较高，但BP是伊朗老年患者中最常见的ABDs，这突出了老年患者BP临床诊断的重要性。
