Cichosz Simon Lebech, Vestergaard Esben Thyssen, Hejlesen Ole
Department of Health Science and Technology, Aalborg University, Denmark.
Department of Pediatrics Randers Regional Hospital and Aarhus University Hospital, Denmark.
Prim Care Diabetes. 2018 Feb;12(1):66-70. doi: 10.1016/j.pcd.2017.06.007. Epub 2017 Jul 10.
This study investigates the role of muscle strength as a predictive factor for reduced pulmonary function in diabetes.
Data from the NHANES 2011-2012 were analyzed. Lung function was assessed with spirometry (FEV1, FVC). Diabetes was assessed with an oral glucose tolerance test (OGTT), glycated hemoglobin (HbA1c), or fasting plasma glucose (FPG). Muscle strength was measured by a grip test using a handgrip dynamometer.
A total of 3521 people were suitable to be included for analysis in this study. Lung function was reduced in diabetes-after adjustment for covariates, the impact of diabetes on FVC was estimated as -331mL (SE 48) for known diabetes and -282mL (SE 41) for undiagnosed diabetes (P<0.001). Grip strength was also reduced in diabetes. After adjustment for covariates, the impact of diabetes was estimated as -5.9kg (SE 0.8) for known diabetes (P<0.001). An association between lung capacity and grip strength in people with known diabetes was observed (R=0.7, P<0.001). The adjusted impact on FVC from grip strength was estimated as 13.1mL (SE 3.4) per kg (P<0.001).
Muscle strength appears to be reduced in people with known diabetes, and this seems to affect the respiratory muscles as an independent factor.
本研究调查肌肉力量作为糖尿病患者肺功能降低预测因素的作用。
分析了2011 - 2012年美国国家健康与营养检查调查（NHANES）的数据。通过肺量计评估肺功能（第一秒用力呼气容积[FEV1]、用力肺活量[FVC]）。通过口服葡萄糖耐量试验（OGTT）、糖化血红蛋白（HbA1c）或空腹血糖（FPG）评估糖尿病。使用握力计通过握力测试测量肌肉力量。
本研究共纳入3521人进行分析。糖尿病患者的肺功能降低——在对协变量进行调整后，已知糖尿病对FVC的影响估计为-331mL（标准误48），未诊断糖尿病对FVC的影响估计为-282mL（标准误41）（P<0.001）。糖尿病患者的握力也降低。在对协变量进行调整后，已知糖尿病对握力的影响估计为-5.9kg（标准误0.8）（P<0.001）。观察到已知糖尿病患者的肺容量与握力之间存在关联（R = 0.7，P<0.001）。握力对FVC的调整影响估计为每千克13.1mL（标准误3.4）（P<0.001）。
已知糖尿病患者的肌肉力量似乎降低，这似乎作为一个独立因素影响呼吸肌。
