Department of General Surgery, Hangzhou Red Cross Hospital/Zhejiang Provincial Integrated Chinese and Western Medicine Hospital, 208 East Road, Hangzhou Ring, Hangzhou, Zhejiang, China.
Department of General Surgery, Hangzhou Red Cross Hospital/Zhejiang Provincial Integrated Chinese and Western Medicine Hospital, 208 East Road, Hangzhou Ring, Hangzhou, Zhejiang, China
Biosci Rep. 2017 Aug 2;37(4). doi: 10.1042/BSR20170872. Print 2017 Aug 31.
The relationship between () gene rs1205 polymorphism and the risk of colorectal cancer (CRC) has been investigated previously. However, the results were conflicting. In the present study, we assessed whether gene rs1205 polymorphism was associated with the risk of CRC by meta-analysis. We searched in PubMed, Embase, and the CNKI databases. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. Seven original studies involving 4,181 cases and 10,601 controls analyzed the association between gene rs1205 polymorphism and CRC risk. No significant association was found between gene rs1205 polymorphism and CRC risk in this meta-analysis. Sensitivity analysis did not draw different findings. Stratification analyses of ethnicity, type of cancer, and genotype method also did not obtain any association between gene rs1205 polymorphism and CRC risk. In conclusion, this meta-analysis indicates that gene rs1205 polymorphism was not associated with the risk of CRC.
先前已经有研究探讨过 () 基因 rs1205 多态性与结直肠癌（CRC）风险之间的关系。然而，研究结果存在争议。本研究通过荟萃分析评估了 基因 rs1205 多态性是否与 CRC 风险相关。我们在 PubMed、Embase 和中国知网数据库中进行了检索。汇总的比值比（OR）和 95%置信区间（CI）进行了计算。有 7 项原始研究共纳入了 4181 例病例和 10601 例对照，分析了 基因 rs1205 多态性与 CRC 风险之间的关联。本荟萃分析未发现 基因 rs1205 多态性与 CRC 风险之间存在关联。敏感性分析也没有得出不同的结果。对种族、癌症类型和基因型方法进行的分层分析也没有发现 基因 rs1205 多态性与 CRC 风险之间存在关联。总之，本荟萃分析表明，基因 rs1205 多态性与 CRC 风险无关。
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