Jafari-Nedooshan Jamal, Dastgheib Seyed Alireza, Kargar Saeed, Zare Mohammad, Raee-Ezzabadi Ali, Heiranizadeh Naeimeh, Sadeghizadeh-Yazdi Jalal, Neamatzadeh Hossein
Department of General Surgery, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Department of Medical Genetics, School of Medicine, Shiraz Sadoughi University of Medical Sciences, Shiraz, Iran.
Acta Medica (Hradec Kralove). 2019;62(4):137-146. doi: 10.14712/18059694.2020.2.
The -174G>C (rs1800795) polymorphism at interleukin 6 (IL-6) gene has been reported to be related with the occurrence of colorectal (CRC) and gastric (GC) cancers. However, the results had been conflicting and controversial. In order to give a comprehensive and precise result, we summarized available data to analyze the association of this polymorphism with CRC and GC risk.
A comprehensive literature search on PubMed, Elsevier Science Direct, and CNKI database was performed to identify all eligible studies up to May 15, 2019. The strength of association was assessed by odds ratios (ORs) with 95% confidence intervals (CI).
A total of 29 case-control studies including 16 studies with 7,560 cases and 9,574 controls on CRC and 13 studies with 1,445 cases and 2,918 controls on GC were selected. Overall, pooled data showed that the IL-6 -174G>C polymorphism was not significantly associated with increased risk of CRC and GC in overall. When stratified by ethnicity, we found a statistically significant association between the IL-6 -174 G>C polymorphism and CRC risk in Asians (CC vs. GG: OR = 1.860, 95% CI 1.061-3.258, p = 0.030; and CC vs. CG+GG: OR = 1.941, 95% CI 1.131-3.331, p = 0.016).
The meta-analysis suggests that IL-6 -174G>C polymorphism was not significantly associated with the increased risk of CRC and GC in overall population. However, the results showed that IL-6 -174G>C polymorphism may be associated with risk of GC in Asians. Further studies including a larger sample size will be necessary to clarify these results.
白细胞介素6（IL-6）基因-174G>C（rs1800795）多态性据报道与结直肠癌（CRC）和胃癌（GC）的发生有关。然而，结果一直存在冲突和争议。为了给出全面准确的结果，我们总结了现有数据以分析该多态性与CRC和GC风险的关联。
在PubMed、爱思唯尔科学Direct和中国知网数据库上进行全面的文献检索，以识别截至2019年5月15日的所有符合条件的研究。关联强度通过比值比（OR）及95%置信区间（CI）进行评估。
共选择了29项病例对照研究，其中16项研究涉及7560例CRC病例和9574例对照，13项研究涉及1445例GC病例和2918例对照。总体而言，汇总数据显示IL-6 -174G>C多态性与总体CRC和GC风险增加无显著关联。按种族分层时，我们发现亚洲人中IL-6 -174 G>C多态性与CRC风险之间存在统计学显著关联（CC与GG：OR = 1.860，95% CI 1.061 - 3.258，p = 0.030；CC与CG + GG：OR = 1.941，95% CI 1.131 - 3.331，p = 0.016）。
荟萃分析表明，IL-6 -174G>C多态性与总体人群中CRC和GC风险增加无显著关联。然而，结果显示IL-6 -174G>C多态性可能与亚洲人GC风险有关。需要进一步开展包括更大样本量的研究以阐明这些结果。
