Kouvonen Anne, Mänty Minna, Lallukka Tea, Pietiläinen Olli, Lahelma Eero, Rahkonen Ossi
Faculty of Social Sciences, University of Helsinki, Helsinki, Finland.
SWPS University of Social Sciences and Humanities in Wroclaw, Wroclaw, Poland.
BMJ Open. 2017 Jul 12;7(7):e015573. doi: 10.1136/bmjopen-2016-015573.
To investigate whether changes in psychosocial and physical working conditions are associated with subsequent psychotropic medication in ageing employees.
Data were from the Helsinki Health Study, a cohort study of Finnish municipal employees, aged 40-60 years at phase 1 (2000-2002). Changes in psychosocial and physical working conditions were measured between phase 1 and phase 2 (2007). Survey data were longitudinally linked to data on prescribed, reimbursed psychotropic medication purchases (Anatomical Therapeutic Chemical) obtained from the registers of the Social Insurance Institution of Finland between the phase 2 survey and December 2013 (N=3587; 80% women). Outcomes were any psychotropic medication; antidepressants (N06A); anxiolytics (N05B); and sedatives and hypnotics (N05C). Cox regression analyses were performed.
During the follow-up, 28% of the participants were prescribed psychotropic medication. Repeated exposures to low job control, high job demands and high physical work load were associated with an increased risk of subsequent antidepressant and anxiolytic medication. Increased and repeated exposure to high physical work load, increased job control and repeated high job demands were associated with subsequent sedative and hypnotic medication. Age and sex-adjusted HR varied from 1.18 to 1.66. Improvement in job control was associated with a lower risk of anxiolytic, but with a higher risk of sedatives and hypnotic medication. Decreased physical work load was associated with a lower risk of antidepressant and anxiolytic medications.
Improvement in working conditions could lower the risk of mental ill-health indicated by psychotropic medication.
调查心理社会和身体工作条件的变化是否与老年员工随后使用精神药物有关。
数据来自赫尔辛基健康研究,这是一项对芬兰市政员工的队列研究,第一阶段(2000 - 2002年)时年龄在40 - 60岁。在第一阶段和第二阶段(2007年)之间测量心理社会和身体工作条件的变化。调查数据与从芬兰社会保险机构登记册中获取的2007年调查至2013年12月期间开具处方并报销的精神药物购买数据(解剖治疗化学分类)纵向关联(N = 3587;80%为女性)。结局指标为任何精神药物;抗抑郁药(N06A);抗焦虑药(N05B);以及镇静催眠药(N05C)。进行了Cox回归分析。
在随访期间,28%的参与者开具了精神药物处方。反复暴露于低工作控制、高工作要求和高体力工作负荷与随后使用抗抑郁药和抗焦虑药的风险增加相关。反复暴露于高体力工作负荷增加、工作控制增加和反复的高工作要求与随后使用镇静催眠药相关。年龄和性别调整后的风险比在1.18至1.66之间。工作控制的改善与使用抗焦虑药的风险降低相关,但与使用镇静催眠药的风险增加相关。体力工作负荷的降低与使用抗抑郁药和抗焦虑药的风险降低相关。
工作条件的改善可以降低精神药物所表明的心身疾病风险。