Ahmad Irshad, AlMallah Abdul Rahman
Department of Mathematics and Natural Sciences, School of Arts and Sciences, American University of Ras Al Khaimah, Ras Al Khaimah, UAE.
Department of Chemical and Petroleum Engineering, School of Engineering, American University of Ras Al Khaimah, Ras Al Khaimah, UAE.
Chirality. 2017 Dec;29(12):798-810. doi: 10.1002/chir.22768. Epub 2017 Sep 29.
Enantiomerically pure secondary alcohols are essential compounds in organic synthesis and are used as chiral auxiliaries and synthetic intermediates in the pharmaceutical, agrochemical, and fine chemical industries. One of the attractive and practical approaches to achieving optically pure secondary alcohols is oxidative kinetic resolution of racemic secondary alcohols using chiral Mn(III) salen complexes. In the last decade, several chiral Mn(III) salen complexes have been reported with excellent enantioselectivity and activity in the homogeneous and heterogeneous catalysis of the oxidative kinetic resolution of racemic secondary alcohols. This review article is an overview of the literature on the recent development of chiral Mn(III) salen complexes for oxidative kinetic resolution of racemic secondary alcohols. The catalytic activity of monomeric, dimeric, macrocyclic, polymeric, and silica/resin supported chiral Mn(III) salen complexes is discussed in detail.
对映体纯的仲醇是有机合成中的重要化合物，在制药、农用化学品和精细化工行业中用作手性助剂和合成中间体。实现光学纯仲醇的一种有吸引力且实用的方法是使用手性Mn(III) 双水杨醛缩乙二胺络合物对外消旋仲醇进行氧化动力学拆分。在过去十年中，已经报道了几种手性Mn(III) 双水杨醛缩乙二胺络合物，它们在对外消旋仲醇氧化动力学拆分的均相和非均相催化中具有优异的对映选择性和活性。这篇综述文章概述了有关手性Mn(III) 双水杨醛缩乙二胺络合物用于外消旋仲醇氧化动力学拆分的最新进展的文献。详细讨论了单体、二聚体、大环、聚合物以及二氧化硅/树脂负载的手性Mn(III) 双水杨醛缩乙二胺络合物的催化活性。
