Manclark C R, Burns D L
Ann Inst Pasteur Microbiol (1985). 1985 Nov-Dec;136B(3):323-9. doi: 10.1016/s0769-2609(85)80077-6.
A number of virulence factors of Bordetella pertussis have been isolated and studied for their roles in pathogenesis and are under consideration, singly and in combinations, for inclusion in candidate acellular pertussis vaccines to be used in clinical trials to demonstrate safety and efficacy. Prospective immunogens would include lymphocytosis-promoting factor, agglutinogens, adenylate cyclase, filamentous haemagglutinin, heat-labile toxin and tracheal cytotoxin. Some of these factors are toxins and would need to be properly toxoided before being formulated into a vaccine. Clinical trials with acellular pertussis vaccines are planned or in progress in several countries.
百日咳博德特氏菌的许多毒力因子已被分离出来，并对其在发病机制中的作用进行了研究，目前正在单独或组合考虑将它们纳入用于临床试验以证明安全性和有效性的候选无细胞百日咳疫苗中。预期的免疫原包括淋巴细胞增多促进因子、凝集原、腺苷酸环化酶、丝状血凝素、不耐热毒素和气管细胞毒素。其中一些因子是毒素，在制成疫苗之前需要进行适当的类毒素处理。几个国家正在计划或进行无细胞百日咳疫苗的临床试验。
