一种无细胞百日咳疫苗的纯化与特性分析
The purification and characterization of an acellular pertussis vaccine.
作者信息
Chazono M, Yoshida I, Konobe T, Fukai K
机构信息
Kanoji Institute, Research Foundation for Microbial Diseases of Osaka University, Kagawa, Japan.
出版信息
J Biol Stand. 1988 Apr;16(2):83-9. doi: 10.1016/0092-1157(88)90035-2.
An acellular pertussis vaccine manufactured by Biken was investigated for purity, potency and toxicity. The vaccine was composed of almost equal proportions of pertussis toxin (PT) and filamentous hemagglutinin (FHA). The purity of the vaccine was 97-99%. The protective effects of component vaccines containing various ratios of PT and FHA were tested and it was found that the ratio of 1:1 provided the most effective vaccine.
对由日本绿十字制药公司生产的无细胞百日咳疫苗进行了纯度、效力和毒性研究。该疫苗由几乎等量的百日咳毒素（PT）和丝状血凝素（FHA）组成。疫苗的纯度为97%-99%。对含有不同比例PT和FHA的组分疫苗的保护效果进行了测试，发现比例为1:1时疫苗效果最为显著。
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