Khalele Bacem A E O
Ministry of Health, Cairo, Egypt.
J Oral Biol Craniofac Res. 2017 May-Aug;7(2):101-105. doi: 10.1016/j.jobcr.2017.04.002. Epub 2017 Apr 14.
Ameloblastoma (AM) and odontogenic Keratocyst (OKC) are destructive odontogenic lesions of the gnathion. Although their exact pathogeneses are not yet totally understood, the viral etiopathogenesis in AM and KCOT has been proposed. True to syndromic keratocystic odontogenic tumor (sKCOT) and non-syndromic OKC is the high recurrence rate.
Given that shared pathways trailed by AM and by sKCOT/OKC have been suggested, this study, however, contrasts the expression of AM and OKC for viral antibodies.
A total of archival 80 paraffin blocks of cases of parakeratinized odontogenic keratocyst (non-syndromic KCOTs) and of ameloblastomas (n = 40 for each) were included in this study to be sectioned and stained for two immunohistochemical markers: anti-human papillomavirus and Epstein-Barr virus-encoded latent membrane protein.
All the submitted cases of AM and parakeratinized OKC were negative for both markers: anti-HPV and anti-LMP-1.
Although results could have been biased, given the same ethnic group and territory examined in this study, all cases were negative for both markers. Therefore, the viral contribution to the etiopathogenesis in AM and OKC could not be established in this study.
成釉细胞瘤（AM）和牙源性角化囊肿（OKC）是颌骨的侵袭性牙源性病变。尽管它们的确切发病机制尚未完全明确，但已有研究提出AM和牙源性角化囊性肿瘤（KCOT）的病毒病因学。综合征性角化囊性牙源性肿瘤（sKCOT）和非综合征性OKC的特点是高复发率。
鉴于AM与sKCOT/OKC之间存在共同的信号通路，本研究对比了AM和OKC中病毒抗体的表达情况。
本研究共纳入80例存档石蜡块，其中包括40例正角化型牙源性角化囊肿（非综合征性KCOT）和40例成釉细胞瘤，将其切片并使用两种免疫组化标志物进行染色：抗人乳头瘤病毒和爱泼斯坦-巴尔病毒编码的潜伏膜蛋白。
所有提交的AM和正角化型OKC病例的两种标志物（抗HPV和抗LMP-1）均为阴性。
尽管本研究中所有病例均来自同一民族和地区，结果可能存在偏差，但两种标志物均为阴性。因此，本研究无法确定病毒在AM和OKC发病机制中的作用。
