牙源性囊肿和肿瘤中病毒的患病率：
Prevalence of Viruses in Odontogenic Cysts and Tumours: .
作者信息
Pandiar Deepak, Gopinath Divya, Pavithran Pinky, Krishnan Reshma Poothakulath, Kumar Jishnu Krishna, Veettil Sajesh K
机构信息
Department of Oral Pathology & Microbiology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India.
Basic Medical and Dental Sciences Dept, College of Dentistry, Ajman University, Ajman, United Arab Emirates.
出版信息
Sultan Qaboos Univ Med J. 2025 May 2;25(1):370-381. doi: 10.18295/2075-0528.2847.
This review aimed to assess the prevalence of oncogenic and non-oncogenic viruses in odontogenic cysts and tumours. A comprehensive database search was performed for published articles regarding the presence of viruses in all odontogenic cysts and tumours, following guidelines without date constraints, and was registered with PROSPERO. After screening 164 articles, 24 studies were included for systematic evaluation. A meta-analysis was performed to determine the prevalence of human papillomavirus (HPV), revealing an overall pooled prevalence of HPV in ameloblastomas of 18.21% (95% confidence interval [CI]: 6.36-33.73) while the prevalence of HPV in odontogenic cysts was found to be 1.51% (95% CI: 0.00-9.46). The prevalence of Epstein-Barr virus in odontogenic tumours was 17.19% (95% CI: 4.62-34.49). Other viruses yielded varied results. Human carcinogenesis has previously been positively correlated with viruses; however, this systematic review's results indicate a very low prevalence in odontogenic pathoses and suggest a limited role in their aetiology.
本综述旨在评估致癌病毒和非致癌病毒在牙源性囊肿和肿瘤中的流行情况。按照无日期限制的指南，对已发表的关于所有牙源性囊肿和肿瘤中病毒存在情况的文章进行了全面的数据库搜索，并在国际前瞻性系统评价注册库（PROSPERO）进行了注册。在筛选了164篇文章后，纳入24项研究进行系统评价。进行了一项荟萃分析以确定人乳头瘤病毒（HPV）的流行情况，结果显示成釉细胞瘤中HPV的总体合并流行率为18.21%（95%置信区间[CI]：6.36 - 33.73），而牙源性囊肿中HPV的流行率为1.51%（95% CI：0.00 - 9.46）。牙源性肿瘤中EB病毒的流行率为17.19%（95% CI：4.62 - 34.49）。其他病毒的结果各不相同。人类致癌作用此前一直与病毒呈正相关；然而，本系统评价的结果表明，在牙源性病变中病毒的流行率非常低，提示其在病因学中的作用有限。
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