Richards William G
Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Ann Transl Med. 2017 Jun;5(11):243. doi: 10.21037/atm.2017.06.26.
Malignant pleural mesothelioma remains a rapidly fatal cancer with few effective therapies. Unusual anatomic features complicate determination of stage and prognosis for individual patients. Validation of staging criteria has been difficult given the rarity of the disease and the fact that only a minority of patients undergo surgical resection with pathological examination of their tumors. Thus, additional heuristic factors and algorithms have been taken into account by clinicians to estimate prognosis and inform discussion of appropriate management strategies or clinical research protocols with patients.
恶性胸膜间皮瘤仍然是一种迅速致命的癌症,有效治疗方法很少。异常的解剖特征使个体患者的分期和预后判定变得复杂。鉴于该疾病的罕见性以及只有少数患者接受肿瘤病理检查的手术切除这一事实,分期标准的验证一直很困难。因此,临床医生已考虑额外的启发式因素和算法来估计预后,并就适当的管理策略或临床研究方案与患者进行讨论。