Sinis Sotirios I, Hatzoglou Chrissi, Gourgoulianis Konstantinos I, Zarogiannis Sotirios G
Department of Physiology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece.
Department of Respiratory Medicine, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece.
Front Physiol. 2018 Mar 29;9:295. doi: 10.3389/fphys.2018.00295. eCollection 2018.
Nanoparticles have great potential for numerous applications due to their unique physicochemical properties. However, concerns have been raised that they may induce deleterious effects on biological systems. There is accumulating evidence that, like asbestos, inhaled nanomaterials of >5 μm and high aspect ratio (3:1), particularly rod-like carbon nanotubes, may inflict pleural disease including mesothelioma. Additionally, a recent set of case reports suggests that inhalation of polyacrylate/nanosilica could in part be associated with inflammation and fibrosis of the pleura of factory workers. However, the adverse outcomes of nanoparticle exposure to mesothelial tissues are still largely unexplored. In that context, the present review aims to provide an overview of the relevant pathophysiological implications involving toxicological studies describing effects of engineered nanoparticles on mesothelial cells and membranes studies primarily emphasize on simulating cellular uptake and toxicity of nanotubes on benign or malignant cell lines. On the other hand, studies focus on illustrating endpoints of serosal pathology in rodent animal models. From a molecular aspect, some nanoparticle categories are shown to be cytotoxic and genotoxic after acute treatment, whereas chronic incubation may lead to malignant-like transformation. At an organism level, a number of fibrous shaped nanotubes are related with features of chronic inflammation and MWCNT-7 is the only type to consistently inflict mesothelioma.
由于其独特的物理化学性质，纳米颗粒在众多应用中具有巨大潜力。然而，人们担心它们可能会对生物系统产生有害影响。越来越多的证据表明，与石棉一样，吸入大于5μm且高纵横比（3:1）的纳米材料，特别是棒状碳纳米管，可能会引发包括间皮瘤在内的胸膜疾病。此外，最近的一组病例报告表明，吸入聚丙烯酸酯/纳米二氧化硅可能部分与工厂工人胸膜的炎症和纤维化有关。然而，纳米颗粒暴露于间皮组织的不良后果仍在很大程度上未被探索。在此背景下，本综述旨在概述相关的病理生理意义，涉及毒理学研究，这些研究描述了工程纳米颗粒对间皮细胞的影响，而膜研究主要侧重于模拟纳米管对良性或恶性细胞系的细胞摄取和毒性。另一方面，研究集中于阐明啮齿动物模型中浆膜病理学的终点。从分子层面来看，一些纳米颗粒类别在急性处理后显示出细胞毒性和基因毒性，而长期孵育可能导致类似恶性的转化。在生物体水平上，一些纤维状纳米管与慢性炎症特征相关，而多壁碳纳米管-7是唯一一种始终会引发间皮瘤的类型。
