Faden A I
Arch Neurol. 1986 May;43(5):501-4. doi: 10.1001/archneur.1986.00520050073026.
It has been proposed that endogenous opioids play a pathophysiologic role in the secondary injury that follows spinal trauma, brain trauma, and cerebral ischemia. Opiate antagonists, at high doses, have been found to improve outcome in various experimental models of central nervous system injury. Thyrotropin-releasing hormone, which appears to act in part as a functional antagonist of opioid systems, has proved effective in the treatment of experimental spinal cord and brain trauma. The literature relating to these developments is reviewed, with emphasis on the potential clinical application of these classes of substances.
有人提出，内源性阿片类物质在脊髓创伤、脑创伤和脑缺血后的继发性损伤中起病理生理作用。已发现高剂量的阿片拮抗剂可改善各种中枢神经系统损伤实验模型的结果。促甲状腺激素释放激素似乎部分作为阿片系统的功能拮抗剂起作用，已被证明在治疗实验性脊髓和脑创伤方面有效。本文回顾了与这些进展相关的文献，重点是这些类物质的潜在临床应用。
