淋巴细胞功能相关抗原-1（LFA-1）的上调使肝脏驻留记忆T细胞能够在肝血窦中巡逻并停留。
Up-regulation of LFA-1 allows liver-resident memory T cells to patrol and remain in the hepatic sinusoids.
作者信息
McNamara H A, Cai Y, Wagle M V, Sontani Y, Roots C M, Miosge L A, O'Connor J H, Sutton H J, Ganusov V V, Heath W R, Bertolino P, Goodnow C G, Parish I A, Enders A, Cockburn I A
机构信息
Department of Immunology and Infectious Disease, John Curtin School of Medical Research, The Australian National University, Canberra, ACT 2602, Australia.
Department of Microbiology, University of Tennessee, Knoxville, Tennessee, United States of America.
出版信息
Sci Immunol. 2017 Mar;2(9). doi: 10.1126/sciimmunol.aaj1996. Epub 2017 Mar 17.
Liver-resident CD8+ T cells are highly motile cells that patrol the vasculature and provide protection against liver pathogens. A key question is: how can these liver CD8+ T cells be simultaneously present in the circulation and tissue-resident? Because liver-resident T cells do not express CD103 - a key integrin for T cell residence in epithelial tissues - we investigated other candidate adhesion molecules. Using intra-vital imaging we found that CD8+ T cell patrolling in the hepatic sinusoids is dependent upon LFA-1-ICAM-1 interactions. Interestingly, liver-resident CD8+ T cells up-regulate LFA-1 compared to effector-memory cells, presumably to facilitate this behavior. Finally, we found that LFA-1 deficient CD8+ T cells failed to form substantial liver-resident memory populations following Plasmodium or LCMV immunization. Collectively, our results demonstrate that it is adhesion through LFA-1 that allows liver-resident memory CD8+ T cells to patrol and remain in the hepatic sinusoids.
肝脏驻留CD8+ T细胞是高度活跃的细胞，它们在脉管系统中巡逻，为肝脏抵御病原体提供保护。一个关键问题是：这些肝脏CD8+ T细胞如何能同时存在于循环系统和组织驻留部位？由于肝脏驻留T细胞不表达CD103（T细胞在上皮组织中驻留的关键整合素），我们研究了其他候选黏附分子。通过活体成像，我们发现肝血窦中CD8+ T细胞的巡逻依赖于LFA-1-ICAM-1相互作用。有趣的是，与效应记忆细胞相比，肝脏驻留CD8+ T细胞上调了LFA-1的表达，推测这有助于这种行为。最后，我们发现LFA-1缺陷的CD8+ T细胞在感染疟原虫或淋巴细胞脉络丛脑膜炎病毒后无法形成大量的肝脏驻留记忆细胞群体。总的来说，我们的结果表明，正是通过LFA-1的黏附作用，肝脏驻留记忆CD8+ T细胞才能在肝血窦中巡逻并留存。
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