Fiocchetti Marco, Cipolletti Manuela, Brandi Valentina, Polticelli Fabio, Ascenzi Paolo
Dipartimento di Scienze, Università Roma Tre, Rome, Italy.
Istituto Nazionale di Fisica Nucleare, Sezione dell'Università Roma Tre, Rome, Italy.
J Mol Recognit. 2017 Dec;30(12). doi: 10.1002/jmr.2654. Epub 2017 Jul 14.
In the year 2000, the third member of the globin family was discovered in human and mouse brain and named neuroglobin (Ngb). Neuroglobin overexpression significantly protects both heart and brain from hypoxic/ischemic and oxidative stress-related insults, whereas decreased Ngb levels lead to an exacerbation of tissue injuries. Moreover, Ngb overexpression protects neurons from mitochondrial dysfunctions and neurodegenerative disorders such as Alzheimer disease; however, it facilitates the survival of cancer cells. Neuroglobin, representing a switch point for cell death and survival, has been reported to recognize a number of proteins involved in several metabolic pathways including ionic homeostasis maintenance, energy metabolism, mitochondrial function, and cell signaling. Here, the recognition properties of Ngb are reviewed to highlight its roles in health and disease.
2000年，珠蛋白家族的第三个成员在人类和小鼠大脑中被发现，并被命名为神经珠蛋白（Ngb）。神经珠蛋白的过表达能显著保护心脏和大脑免受缺氧/缺血以及氧化应激相关的损伤，而神经珠蛋白水平降低则会导致组织损伤加剧。此外，神经珠蛋白的过表达能保护神经元免受线粒体功能障碍和诸如阿尔茨海默病等神经退行性疾病的影响；然而，它却促进癌细胞的存活。据报道，神经珠蛋白作为细胞死亡和存活的一个转换点，能识别多种参与包括离子稳态维持、能量代谢、线粒体功能和细胞信号传导等多种代谢途径的蛋白质。在此，对神经珠蛋白的识别特性进行综述，以突出其在健康和疾病中的作用。
