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钯催化的通过 C-H 活化和区域选择性炔烃插入的螺环化反应。

Palladium-Catalyzed Spirocyclization through C-H Activation and Regioselective Alkyne Insertion.

机构信息

Department of Chemistry, Davenport Chemical Laboratories, University of Toronto, 80 St. George Street, Toronto, Ontario, M5S 3H6, Canada.

出版信息

Angew Chem Int Ed Engl. 2017 Aug 28;56(36):10920-10923. doi: 10.1002/anie.201706325. Epub 2017 Aug 4.

DOI:10.1002/anie.201706325
PMID:28708255
Abstract

A Pd-catalyzed spirocyclization involving a sequential carbopalladation, intramolecular C-H activation, and a highly regioselective alkyne insertion to afford spirooxindoles and spirodihydrobenzofurans has been achieved. The spirocyclic products were generated in good to excellent yields with complete regiocontrol in a readily scalable procedure.

摘要

Pd 催化的螺环化反应涉及顺序碳钯化、分子内 C-H 活化和高度区域选择性的炔烃插入，从而得到螺氧化吲哚和螺二氢苯并呋喃。在易于扩展的程序中，以良好至优异的收率和完全的区域控制生成了螺环产物。

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