钯催化的 C-H 键活化和炔烃插入反应合成二氢苯并吲哚酮。
Palladium-Catalyzed Synthesis of Dihydrobenzoindolones via C-H Bond Activation and Alkyne Insertion.
机构信息
Davenport Research Laboratories, Department of Chemistry , University of Toronto , 80 St. George Street , Toronto , Ontario M5S 3H6 , Canada.
出版信息
Org Lett. 2018 Jul 20;20(14):4367-4370. doi: 10.1021/acs.orglett.8b01856. Epub 2018 Jul 5.
PMID:29975065
Abstract
A palladium-catalyzed intramolecular carbopalladation, intramolecular C-H bond activation, and alkyne insertion sequence for the generation of dihydrobenzoindolones is described. Products are obtained in moderate to excellent yields as single regioisomers. Various functional groups on both reaction partners were tolerated, and the scalability of this method was determined.
摘要
本文描述了一种钯催化的分子内碳钯化、分子内 C-H 键活化和炔烃插入序列，用于生成二氢苯并吲哚酮。作为单区域异构体，以中等至优异的收率获得产物。反应伙伴的各种官能团都可以耐受，并且该方法具有可扩展性。
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