Chervenak Joseph, Sawai Mio, Kabab Lamis El, Lohana Rahul, Skupski Daniel, Witkin Steven S
Division of Immunology and Infectious Diseases, Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY, USA.
Department of Obstetrics and Gynecology, New York Presbyterian Queens, Flushing, New York, NY, USA.
J Perinat Med. 2018 Apr 25;46(3):317-321. doi: 10.1515/jpm-2017-0094.
Factors influencing intraamniotic adiponectin levels and their functional significance remain incompletely elucidated. We prospectively measured adiponectin in amniotic fluid and identified its associations with maternal parameters, mediators in amniotic fluid and pregnancy outcomes.
Mid-trimester amniotic fluid from 571 women was tested for adiponectin, interleukin (IL)-6, IL-8 and α-amylase by enzyme-linked immunosorbant assay (ELISA), after which clinical data were obtained. Correlations between adiponectin and clinical or laboratory variables were analyzed by the Kruskal-Wallis, Mann-Whitney and Spearman rank correlation tests.
As compared to median levels in 462 women with a term delivery (7.8 ng/mL), adiponectin was elevated in 14 women who subsequently developed preterm premature rupture of membranes (pPROM) (17.3 ng/mL) and 24 women with an iatrogenic preterm birth (IPTB) (13.9 ng/mL) (P=0.0003), but not in 30 women who subsequently had a spontaneous preterm birth with intact membranes (8.1 ng/mL) (P>0.05). Median adiponectin was also elevated in 13 women whose babies developed fetal growth restriction (FGR) (20.6 ng/mL) (P=0.0055) and in 22 women whose babies had respiratory distress syndrome (RDS) (23.0 ng/mL) (P<0.0001). The adiponectin concentration was positively correlated with amylase (P=0.0089) and inversely correlated with maternal body mass index (P=0.0045).
Adiponectin is a component of mid-trimester amniotic fluid and its concentration varies with maternal body mass index and subsequent development of pPROM, IPTB, FGR and RDS.
影响羊膜腔内脂联素水平的因素及其功能意义尚未完全阐明。我们前瞻性地测量了羊水脂联素水平，并确定其与母体参数、羊水中介质及妊娠结局之间的关联。
采用酶联免疫吸附测定法（ELISA）检测571名孕中期妇女羊水的脂联素、白细胞介素（IL）-6、IL-8和α-淀粉酶水平，之后获取临床数据。采用Kruskal-Wallis、Mann-Whitney和Spearman等级相关检验分析脂联素与临床或实验室变量之间的相关性。
与462名足月分娩妇女的中位数水平（7.8 ng/mL）相比，14名随后发生胎膜早破（pPROM）的妇女（17.3 ng/mL）和24名医源性早产（IPTB）妇女（13.9 ng/mL）的脂联素水平升高（P=0.0003），但30名随后发生胎膜完整的自然早产妇女（8.1 ng/mL）的脂联素水平未升高（P>0.05）。13名胎儿发生生长受限（FGR）的妇女（20.6 ng/mL）和22名婴儿患有呼吸窘迫综合征（RDS）的妇女（23.0 ng/mL）的脂联素中位数也升高（P=0.0055和P<0.0001）。脂联素浓度与淀粉酶呈正相关（P=0.0089），与母体体重指数呈负相关（P=0.0045）。
脂联素是孕中期羊水的组成部分，其浓度随母体体重指数以及pPROM、IPTB、FGR和RDS的后续发生情况而变化。
