Chair and Department of Obstetrics and Perinatology, Medical University of Lublin, Poland.
II Chair and Department of Gynecology, Medical University of Lublin, Poland.
Biomed Res Int. 2018 Sep 18;2018:7154216. doi: 10.1155/2018/7154216. eCollection 2018.
The aim of this study was to determine any changes in adiponectin and omentin levels in GDM patients who delivered at term and preterm and to evaluate whether adipokines can be useful as a clinical biomarker to predict subsequent preterm delivery.
The levels of adiponectin and omentin were measured in four groups: (1) women with GDM who delivered at term (n=63); (2) women with GDM who had the symptoms of threatened preterm labor and delivered at term (n=23); (3) women with GDM and spontaneous preterm birth (before 37 completed weeks of gestation) (n=19); (4) women with physiological pregnancy (n=55).
In comparison with control group the median adiponectin concentrations were significantly lower in all GDM groups (10737 versus 8879; 7057; 6253 ng/ml, respectively; p<0.01). The median omentin concentrations were also significantly lower in all GDM groups in comparison with control group (469 versus 432; 357; 308 ng/ml, respectively; p<0.01). No significant differences in adiponectin and omentin levels between the GDM, preterm labor, and preterm birth groups were observed. However, there was a trend towards lower adiponectin and omentin levels in preterm birth group. The strong correlations between adiponectin and omentin levels were observed in all groups (R=0.801, p<0.001; R=0.824, p<0.001; R=0.705, p<0.001; R=0.764, respectively; p<0.001). In the univariable logistic regression model, significant correlation between omentin concentrations and preterm birth occurrence was found.
Our findings suggest that omentin-1, rather than adiponectin, could be useful as a predictor of preterm birth in patients with gestational diabetes mellitus.
本研究旨在确定足月和早产分娩的 GDM 患者脂联素和网膜素水平的变化，并评估脂联素等是否可用作预测早产的临床生物标志物。
测量了四组患者的脂联素和网膜素水平：（1）足月分娩的 GDM 患者（n=63）；（2）有早产先兆且足月分娩的 GDM 患者（n=23）；（3）自发性早产（妊娠 37 周前）的 GDM 患者（n=19）；（4）正常妊娠的妇女（n=55）。
与对照组相比，所有 GDM 组的脂联素浓度中位数均显著降低（分别为 10737 与 8879、7057、6253ng/ml；p<0.01）。与对照组相比，所有 GDM 组的网膜素浓度中位数也显著降低（分别为 469 与 432、357、308ng/ml；p<0.01）。GDM、早产先兆和早产组之间的脂联素和网膜素水平无显著差异。然而，早产组的脂联素和网膜素水平呈下降趋势。所有组中均观察到脂联素和网膜素水平之间的强相关性（R=0.801，p<0.001；R=0.824，p<0.001；R=0.705，p<0.001；R=0.764，p<0.001）。在单变量逻辑回归模型中，发现网膜素浓度与早产发生之间存在显著相关性。
我们的研究结果表明，网膜素-1 可能比脂联素更有用，可以作为预测妊娠糖尿病患者早产的指标。
