血压、肾素和醛固酮升高对二肾型Goldblatt高血压大鼠肾钠处理的影响。

Effect of elevated blood pressure, renin and aldosterone on renal sodium handling in two-kidney Goldblatt hypertensive rats.

作者信息

Bikhazi A B, Bitar J N, Birbari A E

出版信息

Comp Biochem Physiol A Comp Physiol. 1986;83(4):785-9. doi: 10.1016/0300-9629(86)90728-0.

Abstract

The effect of elevated blood pressure, renin and aldosterone on renal Na+ retention in two-kidney Goldblatt hypertensive rats were investigated. The technique involved retrograde perfusion from the renal veins via the kidneys, and then through the renal arteries and dorsal aorta. Sodium retention in the stenosed kidney of 7 and 30-60 days post-stenosis hypertensive rats was 82 and 70% higher than in normotensive sham-operated rats respectively. Sodium rention in the clipped kidney, 1 day post-stenosis, was insignificant. However, the contralateral kidney of the 1 day post-stenosis rats retained 27% more Na+. The 1 and 7 days post-stenosis rats had higher plasma aldosterone concentrations than controls, while the 30-60 days post-stenosis rats showed lower levels. The plasma renin activity of the 1 day post-stenosis rats showed 65% higher activity than the sham controls with no significant change in the 30-60 days post-stenosis. Therefore Na+ retention may be mediated by aldosterone in the 7 days post-stenosis rats. Natriuresis in the non-stenosed kidneys of both the 7 and 30-60 days post-stenosis rats may be modulated by an increase in filtration rate due to hypertrophy.

摘要

研究了血压升高、肾素和醛固酮对双肾型Goldblatt高血压大鼠肾脏钠潴留的影响。该技术包括从肾静脉经肾脏进行逆行灌注，然后通过肾动脉和背主动脉。狭窄后7天和30 - 60天的高血压大鼠狭窄肾脏中的钠潴留分别比正常血压假手术大鼠高82%和70%。狭窄后1天，夹闭肾脏中的钠潴留不显著。然而，狭窄后1天大鼠的对侧肾脏钠潴留多27%。狭窄后1天和7天的大鼠血浆醛固酮浓度高于对照组，而狭窄后30 - 60天的大鼠血浆醛固酮水平较低。狭窄后1天大鼠的血浆肾素活性比假手术对照组高65%，狭窄后30 - 60天无显著变化。因此，在狭窄后7天的大鼠中，钠潴留可能由醛固酮介导。狭窄后7天和30 - 60天大鼠非狭窄肾脏中的利钠作用可能因肥大导致滤过率增加而受到调节。