Muñoz-Ramírez H, Chatelain R E, Bumpus F M, Khairallah P A
Am J Physiol. 1980 Jun;238(6):H889-94. doi: 10.1152/ajpheart.1980.238.6.H889.
In Sprague-Dawley rats with unilateral renal artery stenosis and an intact contralateral kidney, administration of a low-sodium diet did not prevent the development of hypertension. Despite an elevated blood pressure, hyponatremia, marked activation of the renin-angiotensin system, and increased hematocrit values, only 10% of the rats showed lesions of malignant hypertension. Systolic blood pressures of one- and two-kidney sham-operated rats fed a low-sodium diet were significantly higher than that of normotensive controls fed a normal diet. Uninephrectomy did not reduce plasma renin activity. The low-sodium diet increased plasma renin activity to about the same level in one- and two-kidney normotensive rats. However, the increase in plasma renin activity elicited by dietary sodium restriction was markedly less in one-kidney Goldblatt hypertension. Systolic blood pressure reached similar levels in one- and two-kidney Goldblatt hypertensive rats fed a low-sodium diet. These data indicate that a decrease in sodium intake does not prevent the development of two-kidney Goldblatt hypertension.
在单侧肾动脉狭窄且对侧肾脏完好的Sprague-Dawley大鼠中，给予低钠饮食并不能预防高血压的发展。尽管血压升高、低钠血症、肾素-血管紧张素系统显著激活以及血细胞比容值增加，但只有10%的大鼠出现恶性高血压病变。喂食低钠饮食的单肾和双肾假手术大鼠的收缩压显著高于喂食正常饮食的正常血压对照组。单侧肾切除并未降低血浆肾素活性。低钠饮食使单肾和双肾正常血压大鼠的血浆肾素活性升高至大致相同水平。然而，在单肾Goldblatt高血压中，饮食钠限制引起的血浆肾素活性增加明显较少。喂食低钠饮食的单肾和双肾Goldblatt高血压大鼠的收缩压达到相似水平。这些数据表明，钠摄入量的减少并不能预防双肾Goldblatt高血压的发展。
