Neurobiology Section, Center for Neural Circuits and Behavior, University of California, San Diego 9500 Gilman Dr., La Jolla, CA 92093, United States.
Max Planck Florida Institute for Neuroscience, 1 Max Planck Way, Jupiter, FL 33458, United States.
Curr Opin Neurobiol. 2017 Aug;45:193-201. doi: 10.1016/j.conb.2017.06.002. Epub 2017 Jul 11.
While it is generally appreciated that learning involves the structural rearrangement of neuronal circuits, the underlying orchestration of molecular events that drives these changes is not as well understood. Recent studies on the spatiotemporal organization of synaptic signaling events have provided new insights into the biochemical underpinnings of various expressions of structural neuronal plasticity, as well as the functional consequences that emerge because of the particular behavior of the molecules involved. In particular, activity patterns of and interplay among a class of morphogenic signaling proteins, the Rho GTPases, and their downstream signals, are found to be critical for linking neuronal activity with various forms of neuronal plasticity. We review recent findings on this topic and discuss their physiological implications.
虽然人们普遍认为学习涉及神经元回路的结构重排，但驱动这些变化的分子事件的底层协调机制还不是很清楚。最近关于突触信号事件的时空组织的研究，为各种结构神经元可塑性的生化基础以及由于涉及的分子的特定行为而产生的功能后果提供了新的见解。特别是，一类形态发生信号蛋白、Rho GTPases 及其下游信号的活动模式和相互作用，被发现对于将神经元活动与各种形式的神经元可塑性联系起来至关重要。我们回顾了这一主题的最新发现，并讨论了它们的生理意义。
