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特应性皮炎中的接触性皮炎考量因素

Contact dermatitis considerations in atopic dermatitis.

作者信息

Rundle Chandler W, Bergman Daniel, Goldenberg Alina, Jacob Sharon E

机构信息

School of Medicine, Loma Linda University, Loma Linda, Loma Linda, CA.

Department of Dermatology, University of California San Diego, CA.

出版信息

Clin Dermatol. 2017 Jul-Aug;35(4):367-374. doi: 10.1016/j.clindermatol.2017.03.009. Epub 2017 Apr 22.

Abstract

Complex immunologic pathways, influenced by both genetic and environment triggers, contribute to the development of atopic dermatitis and allergic contact dermatitis. Suppressing mechanisms between the T1-driven allergic contact dermatitis and the T2-driven atopic dermatitis conditions were thought to reduce the simultaneous expression of both; however, recent evidence indicates that pediatric patients with atopic dermatitis are likely to develop clinically relevant positive patch tests and more likely to react to specific allergens, such as lanolin. We review the potential role of skin barrier defects, such as filaggrin mutations and impaired barrier function, including aberrancies in epidermal pH buffering capabilities, which may promote bacterial biofilms and create an environment favoring sensitization.

摘要

受遗传和环境触发因素影响的复杂免疫途径,促成了特应性皮炎和过敏性接触性皮炎的发展。T1驱动的过敏性接触性皮炎和T2驱动的特应性皮炎之间的抑制机制曾被认为可减少两者的同时表达;然而,最近的证据表明,患有特应性皮炎的儿科患者很可能出现临床上相关的阳性斑贴试验,并且更有可能对特定过敏原(如羊毛脂)产生反应。我们综述了皮肤屏障缺陷的潜在作用,如丝聚合蛋白突变和屏障功能受损,包括表皮pH缓冲能力的异常,这可能会促进细菌生物膜形成,并创造一个有利于致敏的环境。

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