Hanifin Jon M
Department of Dermatology, Oregon Health and Science University, Center for Health and Healing, Portland, Oregon 97239, USA.
J Invest Dermatol. 2008 Jun;128(6):1362-4. doi: 10.1038/sj.jid.5701253.
In this issue, Novak et al. (2008) provide evidence that filaggrin barrier defects might also predispose to allergic contact dermatitis by allowing greater penetration of chemical haptens. Their report provides a fresh perspective on the issues of contact allergy, nickel sensitization, and stratum corneum defects.
在本期杂志中，诺瓦克等人（2008年）提供了证据，表明丝聚合蛋白屏障缺陷可能还会因使化学半抗原更易渗透而导致过敏性接触性皮炎。他们的报告为接触性过敏、镍致敏和角质层缺陷等问题提供了新的视角。
