Ortiz A, Gershon S
J Clin Psychiatry. 1986 May;47 Suppl:3-11.
Neuroleptic drugs have had a great impact on the treatment of psychotic states. The presence of acute and long-term side effects, however, has led to a reconsideration of the risks and benefits of these drugs. The need to use a minimum efficacious dose has led to the implementation of new treatment regimens and attempts to establish a relationship between clinical response and neuroleptic plasma levels. This article will review the factors influencing and conditioning the response to neuroleptic treatment and examine the predictors of good and poor response to neuroleptic drugs. Dopamine-receptor supersensitivity associated with chronic neuroleptic treatment is also considered, as well as new strategies in the treatment of psychotic states.
抗精神病药物对精神状态的治疗产生了重大影响。然而，急性和长期副作用的存在促使人们重新审视这些药物的风险和益处。使用最低有效剂量的需求导致了新治疗方案的实施，并尝试建立临床反应与抗精神病药物血浆水平之间的关系。本文将综述影响和制约抗精神病治疗反应的因素，并探讨抗精神病药物治疗反应良好和不佳的预测因素。还将考虑与慢性抗精神病治疗相关的多巴胺受体超敏反应，以及精神状态治疗的新策略。
