Kane J M, Woerner M, Sarantakos S
J Clin Psychiatry. 1986 May;47 Suppl:30-3.
New research in maintenance drug therapy has been influenced by a need to clarify risk-benefit ratios and determine minimum effective dosages. This research employing controlled study designs and new methods of data analysis has increased our ability to apply findings to specific patients, families, and treatment settings. Results from studies using depot neuroleptics indicate that this methodology may clarify the correlation between dose and blood levels and thus lead to the establishment of generalizable dosage guidelines. Lack of knowledge of maintenance requirements with long-acting injectable drugs may have led to the use of higher doses than necessary and an increased incidence of side effects. Recent studies suggest that with careful clinical observation, substantial reduction of maintenance doses can, for many patients, lead to improvement in some areas of subjective and objective well-being and to a diminution of adverse effects.
维持性药物治疗的新研究受到明确风险效益比和确定最低有效剂量需求的影响。这项采用对照研究设计和新数据分析方法的研究，提高了我们将研究结果应用于特定患者、家庭和治疗环境的能力。使用长效抗精神病药物的研究结果表明，这种方法可能会阐明剂量与血药浓度之间的相关性，从而有助于制定通用的剂量指南。对长效注射药物维持需求缺乏了解，可能导致使用了不必要的高剂量药物，并增加了副作用的发生率。最近的研究表明，通过仔细的临床观察，对于许多患者来说，大幅降低维持剂量可在主观和客观幸福感的某些方面带来改善，并减少不良反应。
