同步和转移性甲状腺乳头状和滤泡状癌的独特分子特征。
Synchronous and Metastatic Papillary and Follicular Thyroid Carcinomas with Unique Molecular Signatures.
机构信息
Department of Pathology, The University of Chicago Medical Center, 5841 South Maryland Ave, Chicago, IL, 60637, USA.
Division of Molecular Pathology, Department of Pathology, The University of Chicago Medical Center, 5841 South Maryland Ave, Chicago, IL, 60637, USA.
出版信息
Endocr Pathol. 2018 Mar;29(1):9-14. doi: 10.1007/s12022-017-9491-6.
Despite the relatively high prevalence of thyroid cancer, the occurrence of multiple synchronous, distinct subtypes of primary thyroid carcinoma is uncommon. The incidental finding of papillary thyroid microcarcinoma in a gland with a biologically relevant follicular or medullary carcinoma is more frequent than the synchronous occurrence of multiple clinically significant carcinomas. We report a case of synchronous papillary and follicular thyroid carcinomas metastatic to lymph node and bone, respectively. Next generation sequencing showed BRAF V600E mutation in the primary papillary carcinoma and NRAS Q61R mutation in the primary follicular carcinoma and bony metastasis. To our knowledge, this is the first reported case of synchronous and metastatic primary papillary and follicular carcinomas, and the first report of synchronous BRAF V600E mutated papillary and NRAS mutated follicular carcinoma.
尽管甲状腺癌的发病率相对较高，但同时发生多种不同类型的原发性甲状腺癌并不常见。在具有生物学意义的滤泡性或髓样癌的腺体中偶然发现甲状腺微小乳头状癌比同时发生多个具有临床意义的癌更为常见。我们报告了一例分别转移至淋巴结和骨骼的同时发生的甲状腺乳头状癌和滤泡状癌。下一代测序显示原发性乳头状癌中存在 BRAF V600E 突变，而原发性滤泡状癌和骨转移中存在 NRAS Q61R 突变。据我们所知，这是首例同时发生和转移的原发性乳头状癌和滤泡状癌的病例，也是首例同时发生 BRAF V600E 突变的乳头状癌和 NRAS 突变的滤泡状癌的病例。
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