Ji Feihong, Qiu Xinguang
Thyroid Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
Pharmaceuticals (Basel). 2022 Dec 15;15(12):1565. doi: 10.3390/ph15121565.
Thyroid disorders are among the most common endocrinological conditions. As the prevalence of thyroid diseases increases annually, the exploration of thyroid disease mechanisms and the development of treatments are also gradually improving. With the gradual advancement of therapies, non-apoptotic programmed cell death (NAPCD) has immense potential in inflammatory and neoplastic diseases. Autophagy, pyroptosis, ferroptosis, and immunogenic cell death are all classical NAPCD. In this paper, we have compiled the recent mechanistic investigations of thyroid diseases and established the considerable progress by NAPCD in thyroid diseases. Furthermore, we have elucidated the role of various types of NAPCD in different thyroid disorders. This will help us to better understand the pathophysiology of thyroid-related disorders and identify new targets and mechanisms of drug resistance, which may facilitate the development of novel diagnostic and therapeutic strategies for patients with thyroid diseases. Here, we have reviewed the advances in the role of NAPCD in the occurrence, progression, and prognosis of thyroid diseases, and highlighted future research prospects in this area.
甲状腺疾病是最常见的内分泌疾病之一。随着甲状腺疾病的患病率逐年上升，对甲状腺疾病机制的探索以及治疗方法的开发也在逐步改进。随着治疗方法的逐步推进，非凋亡性程序性细胞死亡（NAPCD）在炎症性和肿瘤性疾病中具有巨大潜力。自噬、焦亡、铁死亡和免疫原性细胞死亡均为经典的NAPCD。在本文中，我们汇总了甲状腺疾病的近期机制研究，并阐述了NAPCD在甲状腺疾病中的重大进展。此外，我们阐明了不同类型的NAPCD在不同甲状腺疾病中的作用。这将有助于我们更好地理解甲状腺相关疾病的病理生理学，并确定新的靶点和耐药机制，这可能有助于为甲状腺疾病患者开发新的诊断和治疗策略。在此，我们综述了NAPCD在甲状腺疾病发生、发展和预后中的作用进展，并强调了该领域未来的研究前景。
