脑干听觉诱发电位在成人孤独症谱系障碍、注意缺陷多动障碍和精神分裂谱系障碍诊断中的应用。一项盲法研究。
Brainstem Auditory Evoked Potentials for diagnosing Autism Spectrum Disorder, ADHD and Schizophrenia Spectrum Disorders in adults. A blinded study.
机构信息
Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Järva psychiatric out-patient clinic, Praktikertjänst AB, Stockholm, Sweden.
School of Medical Sciences, Örebro University, Örebro, SE-70182 Örebro, Sweden; University Health Care Research Centre, Örebro University, Örebro, Sweden.
出版信息
Psychiatry Res. 2017 Nov;257:21-26. doi: 10.1016/j.psychres.2017.06.085. Epub 2017 Jul 6.
The aim of the present study was to examine the clinical utility of complex auditory brainstem response (c-ABR) and investigate if c-ABR is helpful in the diagnostic procedure. Thirty-one adult psychiatric patients, thoroughly diagnosed with autism spectrum disorder (ASD) (n=16), ADHD (n=8), or schizophrenia spectrum disorder (SSD) (n=7) and 15 healthy controls (HC), were blindly assessed with SensoDetect BERA. This c-ABR correctly identified psychiatric diagnoses in 4 patients (13%) and provided partially correct diagnoses in 11 more patients. Of the 15 HC, 6 were misclassified as psychiatric patients. The Cohen´s kappa coefficient (κ) was substantial for HC (κ=0.67), fair for SSD (κ=0.37), slight for ADHD (κ=0.09) and without agreement in ASD (κ=-0.03). In conclusion, we found the c-ABR method unhelpful and unreliable as a tool in clinical diagnostics.
本研究旨在探讨复杂听觉脑干反应（c-ABR）的临床应用，并研究其在诊断中的作用。31 名成年精神科患者，包括 16 名自闭症谱系障碍（ASD）患者、8 名注意力缺陷多动障碍（ADHD）患者和 7 名精神分裂症谱系障碍（SSD）患者，以及 15 名健康对照组（HC），均接受了 SensoDetect BERA 的盲法评估。该 c-ABR 正确识别了 4 名患者（13%）的精神科诊断，并对另外 11 名患者提供了部分正确诊断。15 名 HC 中，有 6 名被错误分类为精神科患者。HC 的 Cohen's kappa 系数（κ）为 0.67，SSD 为 0.37，ADHD 为 0.09，而 ASD 则无一致性（κ=-0.03）。总之，我们发现 c-ABR 方法在临床诊断中无用且不可靠。
Zotero 插件