Department of Neuroscience, Psychiatry and Uppsala University Hospital, Uppsala University, Uppsala, Sweden.
Acta Neuropsychiatr. 2020 Aug;32(4):214-217. doi: 10.1017/neu.2020.7. Epub 2020 Feb 17.
The aim of the study was to assess whether the auditory brainstem response (ABR) profiling test for schizophrenia (SZ) would recognise schizoaffective disorder (SZA) patients as SZ or not.
Male and female SZA patients (n = 16) from the psychosis unit at Uppsala University Hospital were investigated. Coded sets of randomised ABR recordings intermingled with patients with SZ, adult attention-deficit hyperactivity disorder (ADHD) and healthy controls were analysed by an independent party blinded to clinical diagnoses.
The ABR profiling test for SZ was positive in 5/16 patients (31%) and negative in 11/16 patients (69%) with SZA. A surprising finding was that 4/16 (25%) SZA patients were positive for the ABR profiling test for ADHD.
With the ABR profiling test, a minority of patients with SZA tested positive for SZ. In contrast, a majority (85%) of patients with SZ in a previous study tested positive. These preliminary results leave us ignorant whether SZA should be regarded as a SZ-like disorder or a psychotic mood disorder and add to the questions regarding the validity of this diagnostic entity. However, the ABR profiling method is still in its infancy and its exploration in a range of psychiatric disorders is warranted.
本研究旨在评估听觉脑干反应（ABR）分析测试能否将分裂情感性障碍（SZA）患者识别为精神分裂症（SZ）。
对乌普萨拉大学医院精神病科的男性和女性 SZA 患者（n=16）进行了研究。通过独立的、对临床诊断不知情的第三方对混合有 SZ、成人注意缺陷多动障碍（ADHD）和健康对照者的随机 ABR 记录编码集进行分析。
16 例 SZA 患者中，5 例（31%）ABR 分析测试阳性，11 例（69%）阴性。一个令人惊讶的发现是，16 例 SZA 患者中有 4 例（25%）对 ADHD 的 ABR 分析测试呈阳性。
通过 ABR 分析测试，少数 SZA 患者对 SZ 呈阳性反应。相比之下，在之前的一项研究中，大多数（85%）SZ 患者的测试结果呈阳性。这些初步结果使我们无法确定 SZA 是否应被视为类似 SZ 的障碍或精神病性情绪障碍，并增加了对这一诊断实体有效性的质疑。然而，ABR 分析方法仍处于起步阶段，需要在一系列精神障碍中进行探索。
