Department of Neuroscience, Psychiatry,Uppsala University,Uppsala University Hospital,Uppsala,Sweden.
Acta Neuropsychiatr. 2018 Jun;30(3):137-147. doi: 10.1017/neu.2017.24. Epub 2017 Aug 14.
To evaluate the performances of two auditory brainstem response (ABR) profiling tests as potential biomarkers and diagnostic support for schizophrenia and adult attention-deficit hyperactivity disorder (ADHD), respectively, in an investigator-initiated blinded study design.
Male and female patients with schizophrenia (n=26) and adult ADHD (n=24) meeting Diagnostic and Statistical Manual of Mental Disorders Fourth Edition (DSM IV) diagnostic criteria and healthy controls (n=58) comprised the analysis set (n=108) of the total number of study participants (n=119). Coded sets of randomized ABR recordings were analysed by an independent party blinded to clinical diagnoses before a joint code-breaking session.
The ABR profiling test for schizophrenia identified schizophrenia patients versus controls with a sensitivity of 84.6% and a specificity of 93.1%. The ADHD test identified patients with adult ADHD versus controls with a sensitivity of 87.5% and a specificity of 91.4%.
The ABR profiling tests discriminated schizophrenia and ADHD versus healthy controls with high sensitivity and specificity. The methods deserve to be further explored in larger clinical studies including a broad range of psychiatric disorders to determine their utility as potential diagnostic biomarkers.
在一项由研究者发起的、盲法设计的研究中，评估两种听觉脑干反应（ABR）分析测试作为精神分裂症和成人注意缺陷多动障碍（ADHD）潜在生物标志物和诊断支持的性能。
符合《精神障碍诊断与统计手册（第四版）》（DSM-IV）诊断标准的男性和女性精神分裂症患者（n=26）和成人 ADHD 患者（n=24）以及健康对照者（n=58）构成了研究参与者总数（n=119）的分析集（n=108）。在联合破解代码会议之前，由一个独立的、对临床诊断不知情的第三方对随机 ABR 记录的编码集进行分析。
用于精神分裂症的 ABR 分析测试将精神分裂症患者与对照者区分开来，其敏感性为 84.6%，特异性为 93.1%。ADHD 测试将患有成人 ADHD 的患者与对照者区分开来，其敏感性为 87.5%，特异性为 91.4%。
ABR 分析测试以高灵敏度和特异性区分了精神分裂症和 ADHD 与健康对照者。这些方法值得在更大的临床研究中进一步探索，包括广泛的精神障碍，以确定它们作为潜在诊断生物标志物的效用。
