Iriuchijima J, Sakata S
Jpn J Physiol. 1985;35(6):1051-63. doi: 10.2170/jjphysiol.35.1051.
Regional differences in sympathetic vasoconstrictor tone were studied in conscious rats. In each rat an electromagnetic flow probe was chronically implanted around the common carotid, superior mesenteric, or renal artery, or the terminal aorta. An indwelling catheter for the measurement of arterial pressure was inserted into the terminal aorta via the right femoral artery. Peripheral resistance was calculated by dividing arterial pressure by flow. The per cent decrease in peripheral resistance on the ganglion blockade with hexamethonium bromide was used as a measure of regional sympathetic vasoconstrictor tone. A significant decrease in peripheral resistance, assumed to indicate a substantial tonic discharge to resistance vessels, was observed in conscious rats only in the carotid and renal areas and not in the superior mesenteric and hindquarter (supplied by the terminal aorta) areas. Since ganglion blockade also diminished the sum of the mean regional flows, cardiac output was estimated to decrease on the ganglion blockade. This suggests that capacitance vessels are also receiving a sizable vasoconstrictor tone, because the ganglion blockade did not elevate right atrial pressure. Pentobarbital anesthesia markedly inhibited the assumed tone to the renal area and was estimated to newly generate a tone to the hindquarters.
在清醒大鼠中研究了交感缩血管紧张的区域差异。在每只大鼠的颈总动脉、肠系膜上动脉、肾动脉或主动脉末端周围长期植入电磁血流探头。通过右股动脉将用于测量动脉压的留置导管插入主动脉末端。外周阻力通过动脉压除以血流量来计算。用溴化六甲铵阻断神经节后外周阻力的降低百分比作为区域交感缩血管紧张的指标。仅在清醒大鼠的颈动脉和肾区观察到外周阻力显著降低，这被认为表明对阻力血管有大量的紧张性放电，而在肠系膜上动脉和后肢（由主动脉末端供血）区域未观察到。由于神经节阻断也减少了平均区域血流量的总和，因此估计神经节阻断时心输出量会降低。这表明容量血管也接受相当大的缩血管紧张，因为神经节阻断并未升高右心房压力。戊巴比妥麻醉明显抑制了假定的肾区紧张，并估计新产生了后肢的紧张。
