重复经颅磁刺激的作用机制：基于动物研究的一个工作假说
Mechanism of Action for rTMS: A Working Hypothesis Based on Animal Studies.
作者信息
Soundara Rajan Thangavelu, Ghilardi Maria F M, Wang Hoau-Yan, Mazzon Emanuela, Bramanti Placido, Restivo Domenico, Quartarone Angelo
机构信息
Department of Experimental Neurology and Clinical Neurophysiology, Centro Neurolesi Bonino Pulejo (IRCCS)Messina, Italy.
Department of Physiology, Pharmacology and Neuroscience, Sophie Davis School for Biomedical Education at City College of New York, City University of New YorkNew York, NY, United States.
出版信息
Front Physiol. 2017 Jun 30;8:457. doi: 10.3389/fphys.2017.00457. eCollection 2017.
Abstract
Experiments in rodents have elucidated some of the molecular mechanisms underlying repetitive transcranial magnetic stimulation (rTMS). These studies may be useful in a translational perspective so that future TMS studies in rodents can closely match human TMS protocols designed for therapeutic purposes. In the present work we will review the effects of rTMS on glutamate neurotransmission which in turn induce persistent changes in synaptic activity. In particular, we will focus on the role of NMDA and non-NMDA transmission and on the permissive role of BDNF-TrKB interaction in the rTMS induced after-effects.
摘要
对啮齿动物的实验已经阐明了重复经颅磁刺激（rTMS）背后的一些分子机制。从转化医学的角度来看，这些研究可能会有所帮助，这样未来在啮齿动物身上进行的TMS研究就能与为治疗目的而设计的人类TMS方案紧密匹配。在本研究中，我们将综述rTMS对谷氨酸能神经传递的影响，而谷氨酸能神经传递反过来又会引起突触活动的持续变化。特别是，我们将聚焦于NMDA和非NMDA传递的作用，以及脑源性神经营养因子（BDNF）与酪氨酸激酶受体B（TrKB）相互作用在rTMS诱导的后效应中的许可作用。
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