Xiu Linlin, Zhong Gansheng, Liu Dianna, Chen Shaohong, Liu Haiyan, Chen Feng
Beijing University of Chinese Medicine, Beijing, China.
Evid Based Complement Alternat Med. 2017;2017:3526186. doi: 10.1155/2017/3526186. Epub 2017 Jun 21.
Haizao Yuhu Decoction has been widely used to treat thyroid-related diseases especially goiter with few side effects in traditional Chinese medicine (TCM), including herb pair (HZ) and Glycyrrhizae Radix et Rhizoma (GC), as one of "eighteen antagonistic medicaments." The two different species of , (Sf) and (Sp), are not clearly differentiated in clinical use, so that herb pair Sf-GC and Sp-GC could show different effect and toxicity.
We investigated the antigoitrous effect and toxicity and clarified the potential underlying mechanism of the two different species of in HYD (HYDf and HYDp) in PTU-reduced goiter rats.
The results demonstrated that both HYDf and HYDp could exhibit antigoitrous effect through alterations in hypothalamus-pituitary-thyroid (HPT) axis and inhibition of the TPO gene expression; there is no difference in the antigoitrous effects between the two different species of application in HYD.
This study evaluated the safety and efficacy of herb pair HZ-GC applied in HYD in goiter rats at molecular, cellular, and whole level and compared the two species of further. We provide a reliable way to clarify the possible mechanism of the antagonistic medicament herb pair HZ-GC for its application.
海藻玉壶汤在中医领域已被广泛用于治疗甲状腺相关疾病，尤其是甲状腺肿，且副作用较少，其中包含“十八反”中的药对（HZ）和甘草（GC）。临床应用中，羊栖菜（Sf）和海蒿子（Sp）这两种不同的海藻未被明确区分，因此药对Sf - GC和Sp - GC可能表现出不同的作用和毒性。
我们研究了海藻玉壶汤中两种不同海藻（HYDf和HYDp）对丙硫氧嘧啶诱导甲状腺肿大鼠的抗甲状腺肿作用和毒性，并阐明其潜在机制。
结果表明，HYDf和HYDp均可通过改变下丘脑 - 垂体 - 甲状腺（HPT）轴和抑制甲状腺过氧化物酶（TPO）基因表达发挥抗甲状腺肿作用；海藻玉壶汤中两种不同海藻的抗甲状腺肿作用无差异。
本研究在分子、细胞和整体水平评估了海藻玉壶汤中海藻 - 甘草药对在甲状腺肿大鼠中的安全性和有效性，并进一步比较了两种海藻。我们为阐明相反药对海藻 - 甘草在应用中的可能机制提供了可靠方法。
