生长抑素和（D-色氨酸8，D-半胱氨酸14）-生长抑素可延缓大鼠的消退，并逆转电休克诱导的大鼠失忆。

Somatostatin and (D-Trp8, D-Cys14)-somatostatin delay extinction and reverse electroconvulsive shock induced amnesia in rats.

作者信息

Vécsei L, Bollók I, Penke B, Telegdy G

出版信息

Psychoneuroendocrinology. 1986;11(1):111-5. doi: 10.1016/0306-4530(86)90037-5.

Abstract

In the present study the effects of somatostatin and its analogs on active avoidance behavior, electroconvulsive shock (ECS)-induced retrograde amnesia, and spatial-discrimination learning were compared in rats. (D-Trp8, D-Cys14)-somatostatin (as did the somatostatin molecule itself) delayed the extinction of active avoidance behavior, antagonized ECS-induced amnesia, and did not modify spatial-discrimination learning. Des-Asn5-(D-Trp8, D-Ser13) somatostatin and des-AA1,2,4,5,12,13,-(D-Trp8) somatostatin did not influence these behaviors. The data suggest that certain parts of the somatostatin molecule are important for its behavioral actions.

摘要

在本研究中，比较了生长抑素及其类似物对大鼠主动回避行为、电休克（ECS）诱导的逆行性遗忘和空间辨别学习的影响。（D-色氨酸8，D-半胱氨酸14）-生长抑素（与生长抑素分子本身一样）延迟了主动回避行为的消退，拮抗了ECS诱导的遗忘，并且未改变空间辨别学习。去天冬酰胺5-（D-色氨酸8，D-丝氨酸13）生长抑素和去氨基酸1,2,4,5,12,13-（D-色氨酸8）生长抑素对这些行为没有影响。数据表明，生长抑素分子的某些部分对其行为作用很重要。